Table 1.

Susceptibilities of 5,558 clinical isolates to ertapenem and three comparator drugs

Microorganism(s) (no. of isolates) and antimicrobial agentbMIC (μg/ml)
Range50%90%
Acinetobacterspp.a(86)
 Ertapenem0.06–>164.016
 Imipenem≤0.008–>160.252.0
 Amox-clav0.06–>3216>32
 Ciprofloxacin≤0.008–>161.0>16
Aeromonas spp.c(21)
 Ertapenem0.03–1.00.060.25
 Imipenem0.25–4.00.52.0
 Amox-clav16–>3232>32
 Ciprofloxacin≤0.008–1.00.0160.12
Burkholderia cepacia(13)
 Ertapenem4.0–>168.0>16
 Imipenem8.0–>1616>16
 Amox-clav32–32>32>32
 Ciprofloxacin1.0–>164.0>16
Citrobacter spp.d(216)
 Ertapenem≤0.008–4.0≤0.0080.25
 Imipenem0.06–2.00.51.0
 Amox-clav2.0–>3216>32
 Ciprofloxacin≤0.008–>160.031.0
Enterobacter spp.e(239)
 Ertapenem≤0.008–>160.030.5
 Imipenem0.12–>161.02.0
 Amox-clav1.0–>32>32>32
 Ciprofloxacin≤0.008–>160.031.0
Escherichia coli(254)
 Ertapenem≤0.008–0.5≤0.0080.016
 Imipenem0.06–2.00.120.25
 Amox-clav1.0–>328.032
 Ciprofloxacin≤0.008–>160.030.06
Klebsiella spp.f(359)
 Ertapenem≤0.008–>16≤0.0080.03
 Imipenem0.06–>160.250.5
 Amox-clav1.0–>324.016
 Ciprofloxacin≤0.008–>160.061.0
Pasteurella multocida(22)
 Ertapenem≤0.008–0.030.0160.03
 Imipenem0.03–0.50.250.5
 Amox-clav0.06–0.50.250.5
 Ciprofloxacin≤0.008–0.06≤0.0080.016
Proteeaeg(284)
 Ertapenem≤0.008–4.00.0160.03
 Imipenem0.016–164.04.0
 Amox-clav0.5–>3216>32
 Ciprofloxacin≤0.008–>160.06>16
Pseudomonas aeruginosa(161)
 Ertapenem0.12–>168.0>16
 Imipenem0.25–>162.08.0
 Amox-clav32–>32>32>32
 Ciprofloxacin0.03–>160.5>16
Pseudomonas spp.h(29)
 Ertapenem≤0.008–>168.0>16
 Imipenem0.12–>161.0>16
 Amox-clav1.0–>32>32>32
 Ciprofloxacin≤0.008–>160.251.0
Salmonellaspp.i(112)
 Ertapenem≤0.008–0.06≤0.008≤0.008
 Imipenem0.12–1.00.250.5
 Amox-clav1.0–>321.016
 Ciprofloxacin≤0.008–0.120.0160.03
Serratia marcescens(110)
 Ertapenem≤0.008–>160.030.12
 Imipenem0.12–>161.02.0
 Amox-clav4.0–>32>32>32
 Ciprofloxacin≤0.008–>160.254.0
Shigella spp.j(37)
 Ertapenem≤0.008≤0.008≤0.008
 Imipenem0.06–0.50.250.25
 Amox-clav4.0–321632
 Ciprofloxacin≤0.008–0.25≤0.0080.06
Stenotrophomonas maltophilia(54)
 Ertapenem1.0–>16>16>16
 Imipenem8.0–>16>16>16
 Amox-clav4.0–>32>32>32
 Ciprofloxacin1.0–>168.0>16
Miscellaneous gram-negative bacteriak(22)
 Ertapenem≤0.008–>160.034.0
 Imipenem0.06–>161.04.0
 Amox-clav0.12–>328.032
 Ciprofloxacin≤0.008–>160.54.0
Haemophilus spp.l(332)
 Ertapenem≤0.008–0.50.030.06
 Imipenem≤0.008–2.00.51.0
 Ampicillin0.12–>4.00.5>4.0
 Ciprofloxacin≤0.008–160.0160.03
Moraxella catarrhalis(181)
 Ertapenem≤0.008–0.25≤0.0080.016
 Imipenem≤0.008–1.00.120.25
 Ampicillin≤0.03–1.00.250.5
 Ciprofloxacin≤0.008–0.50.0160.03
Neisseria meningitidis(27)
 Ertapenem≤0.008–0.03≤0.0080.016
 Imipenem0.03–1.00.250.5
 Ampicillin0.12–0.50.120.25
 Ciprofloxacin≤0.008≤0.008≤0.008
Corynebacterium spp.m(29)
 Ertapenem≤0.008–>160.5>16
 Imipenem≤0.008–>161.0>16
 Amox-clav≤0.03–>320.5>32
 Ciprofloxacin0.5–>16>16>16
Enterococcus faecalisn(387)
 Ertapenem0.06–>168.0>16
 Imipenem0.03–>162.016
 Amox-clav0.06–>320.51.0
 Ciprofloxacin0.25–>161.0>16
Enterococcus faeciumo(140)
 Ertapenem0.12–>16>16>16
 Imipenem0.25–>16>16>16
 Amox-clav0.06–>32>32>32
 Ciprofloxacin0.25–>16>16>16
Enterococcus spp.p(other) (23)
 Ertapenem0.5–>168.0>16
 Imipenem0.03–>164.0>16
 Amox-clav0.12–>321.032
 Ciprofloxacin0.06–>162.0>16
Staphylococcus aureus
 Oxacillin susceptible (375)
  Ertapenem0.03–>160.120.25
  Imipenem0.016–>160.0160.03
  Amox-clav0.06–8.01.01.0
  Ciprofloxacin0.03–>160.250.5
 Oxacillin resistant (172)
  Ertapenem0.12–>16>16>16
  Imipenem0.03–>1616>16
  Amox-clav0.12–>32>32>32
  Ciprofloxacin0.12–>16>16>16
Staphylococcus spp., coagulase negative Oxacillin susceptible (182)
 Ertapenem0.03–4.00.120.5
 Imipenem≤0.008–1.00.0160.06
 Amox-clav≤0.03–320.254.0
 Ciprofloxacin0.03–2.00.250.5
Oxacillin resistant (346)
 Ertapenem0.06–>168.0>16
 Imipenem≤0.008–>161.0>16
 Amox-clav0.12–>3232>32
 Ciprofloxacin0.06–>168.0>16
Streptococcus agalactiae(206)
 Ertapenem0.016–0.250.060.06
 Imipenem≤0.008–0.060.0160.03
 Amox-clav≤0.03–0.120.060.12
 Ciprofloxacin0.5–4.01.01.0
Streptococcus pneumoniae
 Penicillin susceptible (373)
  Ertapenem≤0.008–0.060.0160.03
  Imipenem≤0.008–0.03≤0.0080.016
  Amox-clav0.06–0.250.060.06
  Ciprofloxacin0.5–161.02.0
 Penicillin intermediate (93)
  Ertapenem≤0.008–1.00.250.5
  Imipenem≤0.008–0.50.120.25
  Amox-clav≤0.03–2.00.51.0
  Ciprofloxacin0.5–161.02.0
 Penicillin resistant (110)
  Ertapenem0.12–4.01.02.0
  Imipenem0.12–2.00.251.0
  Amox-clav0.12–8.01.08.0
  Ciprofloxacin0.5–8.01.02.0
Streptococcus pyogenes(238)
 Ertapenem≤0.008–0.25≤0.0080.016
 Imipenem≤0.008–0.06≤0.008≤0.008
 Amox-clav≤0.03–0.12≤0.03≤0.03
 Ciprofloxacin0.12–2.00.51.0
Streptococcus spp.q(other) (77)
 Ertapenem≤0.008–4.00.120.5
 Imipenem≤0.008–2.00.0160.12
 Amox-clav≤0.03–8.0≤0.030.25
 Ciprofloxacin0.016–160.58.0
Miscellaneous gram-positive bacteriar(38)
 Ertapenem≤0.008–>160.252.0
 Imipenem≤0.008–4.00.030.12
 Amox-clav0.03–>320.120.5
 Ciprofloxacin0.03–>161.04.0
Bacteroides fragilis(56)
 Ertapenem0.016–4.00.251.0
 Imipenem≤0.008–2.00.120.5
Bacteroides spp.s(64)
 Ertapenem0.03–8.00.52.0
 Imipenem0.03–4.00.251.0
Clostridium perfringens(21)
 Ertapenem≤0.008–0.120.060.06
 Imipenem0.03–0.50.060.12
Proprionibacterium acnes(21)
 Ertapenem0.03–4.00.060.25
 Imipenem≤0.008–1.0≤0.0080.03
Miscellaneous anaerobest(48)
 Ertapenem≤0.008–4.00.120.5
 Imipenem≤0.008–2.00.060.25
  • a Species (no. of isolates): A. anitratus (12), A. baumannii(59), A. haemolyticus (8), andA. lwoffii (7).

  • b Amox-clav, amoxicillin-clavulanate.

  • c Species (no. of isolates) A. caviae (3), A. hydrophila(11), and Aeromonas spp. NOS (7).

  • d Species (no. of isolates): C. amalonaticus (8), C. brackii(1), C. diversus (18), C. farmeri (3), C. freundii(119), C. koseri (66), andCitrobacter spp. NOS (1).

  • e Species (no. of isolates): E. aerogenes (111), E. agglomerans(9), E. asburiae (1), E. cancerogenus (1), E. cloacae(112), E. intermedius (2),E. sakasaki (1), and Enterobacterspp. NOS (2).

  • f Species (no. of isolates): K. ornitholytica (1), K. oxytoca(103), and K. pneumoniae (255).

  • g Species (no. of isolates): M. morganii (94), P. mirabilis(113), P. vulgaris (25), P. rettgeri (18), and P. stuartii(34).

  • h Species (no. of isolates): P. fluorescens/putida group (22), P. paucimobilis (1), P. stutzeri(2), P. vesiculare (1), andPseudomonas spp. NOS (3).

  • i Species (no. of isolates): S. enterica serovar Tyhi (3) and non-serovar Typhi salmonellae (109).

  • j Species (no. of isolates): S. bovdii (1), S. flexneri (7),S. sonnei (27), and Shigella spp. NOS (2).

  • k Species (no. of isolates): Alcaligenes faecalis (5), Bordetella bronchiseptica(1), Brevundimonas vesicularis(1), Commamonas spp. (1),Flavobacterium breve (1), F. mengosepticum (1), Hafnia alvei(2), Pasteurella spp. NOS (2),Serratia liquefaciens (1), S. rubidaea (1), Shawanella putrefaciens(1), and Yersinia enterocolitica(5).

  • l Species (no. of isolates): H. aegypticus (1), H. aphrophilus(3), H. haemolyticus (4), H. influenzae (233; 86 β-lactamase-positive), H. parahaemolyticus (1), and H. parainfluenzae (30).

  • m Species (no. of isolates): C. afermentans (1), C. amycolatum(1), C. jeikeium (7; resistant to all drugs), C. pseudodiphtheriticum (1),C. striatum (3), C. ureolyticum(3; resistant to all drugs), andCorynebacterium spp. NOS (13).

  • n Includes 10 vancomycin-resistant strains.

  • o Includes 90 vancomycin-resistant strains.

  • p Species (no. of isolates): E. avium (9), E. casseliflavus(3), E. durans (1), E. gallinarum (8), E. raffinosus(1), and Enterococcus spp. NOS (1).

  • q Species (no. of isolates): group C (5), group F (6), group G (21),S. bovis (6), S. milleri(13), S. mitis (2), S. mutans (2), S. salivarius(3), S. sanguis (4), and S. viridans NOS (15).

  • r Species (no. of isolates):Aerococcus spp. NOS (2), A. urinae(4), Bacillus spp. NOS (8),Lactobacillus spp. NOS (10),Micrococcus spp. NOS (13), and L. monocytogenes (1).

  • s Species (no. of isolates): B. fragilis group, NOS (9), B. ovatus(9), B. thetaiotaomicron (19),B. uniformis (11), B. vulgatus(5), and Bacteroides spp. NOS (11).

  • t Species (no. of isolates):Actinomyces spp. (9),Bifidobacterium spp. (2),Clostridium spp. NOS (9), Eubacterium lentum (2), Fusobacterium spp. (6), Peptostreptococcus spp. (10),Prevotella spp. (6),Propionibacterium spp. NOS (3), andVeillonella parvula (1).