Table 5.

Ravuconazole (BMS-207147) MICs for Aspergillusspp. in eight laboratoriesa

Isolate(s) (no. tested) and MIC criterionMIC range (MIC90 or modal MIC)b
RPMIRPMI-2%M3M3-2%
Itraconazole susceptible (12)
 MIC-00.12–4 (2)0.12–>8 (1)0.2–>8 (4)0.2–>8 (4)
 MIC-20.01–1 (1)0.01–0.5 (0.5)0.01–4 (1)0.06–1 (1)
Itraconazole resistant (isolate no. 5)
 MIC-00.2–0.5 (0.2)0.12–1 (0.2)0.2–8 (0.5)0.12–4 (1)
 MIC-20.01–0.2 (0.12)0.03–0.12 (0.06)<0.008–0.5 (0.12)0.008–0.5 (0.06)
Itraconazole resistant (isolate no. 6)
 MIC-02–8 (2)1–>8 (2)1–>8 (8)2–>8 (8)
 MIC-20.2–4 (0.5)0.12–1 (1)0.2–4 (2)0.062–8 (2)
Voriconazole-resistant mutant (1)
 MIC-02–>8 (4)1–4 (2)4–>8 (>8)2–>8 (8)
 MIC-20.12–4 (1)0.06–1 (0.5)0.06–2 (0.5)0.03–1 (0.2)
  • a Species tested were A. fumigatus ( n = 9 ), A. flavus( n = 3 ), and A. terreus ( n = 3 ); see Table 1 for reported data regarding isolates 5 and 6; 48-h MICs are shown.

  • b MICs are reported in micrograms per milliliter; the MIC90 is reported for susceptible isolates and the modal MIC is reported for single resistant isolates.