Table 2.

Mutations in QRDRs of the gyrA andparC genes of representative mutant strains

Selecting quinoloneStrainMutationa
gyrAparC
GatifloxacinGF9821S81(TCC)→Y(TAC)None
GF9822S81(TCC)→F(TTC)None
AM-1121219841NoneD83(GAT)→N(AAT)
219842NoneS79(TCT)→Y(TAT)
CiprofloxacinCF9841NoneS79(TCT)→Y(TAT)
CF9842NoneD83(GAT)→N(AAT)
  • a No mutant was obtained by selection with AM-1147 at the MIC or higher concentrations. The codon positions of gyrA and parC are according to the numbering of Balas et al. (3) and Pan and Fisher (25), respectively.