Parameter^{a} | Median (range) value^{b} |
---|---|

k_{el} (h^{−1}) | 0.059 (0.039–0.13) |

t_{1/2} (h) | 11.7 (5.3–17.6) |

T_{max} (h) | 2.0 (1.7–4) |

C_{max} (μg/ml) | 37.8 (27.1–54.7) |

AUC_{last} (μg · h/ml) | 246.7 (69.6–353.1) |

AUC_{0–∞} (μg · h/ml) | 827.6 (208.5–1,139.7) |

CL/F (liters/h) | 1.9 (1.4–7.7) |

V/F (liters) | 36.4 (28.6–58.5) |

↵a

*k*_{el}, elimination rate constant;*t*_{1/2}, half-life;*T*_{max}, time to*C*_{max};*C*_{max}, maximal serum concentration; AUC_{last}, area under the serum concentration-versus-time curve at the time of the last concentration determination; AUC_{0–∞}, area under the serum concentration-versus-time curve from time zero to infinity; CL, clearance;*V*, volume of distribution;*F*, bioavailability (which was assumed to be 1 for purposes of analysis).↵b Data are for 10 patients receiving pyrazinamide.