TABLE 2

Noncompartmental analysis of serum pyrazinamide concentrations

ParameteraMedian (range) valueb
kel (h−1)0.059 (0.039–0.13)
t1/2 (h)11.7 (5.3–17.6)
Tmax (h)2.0 (1.7–4)
Cmax (μg/ml)37.8 (27.1–54.7)
AUClast (μg · h/ml)246.7 (69.6–353.1)
AUC0–∞ (μg · h/ml)827.6 (208.5–1,139.7)
CL/F (liters/h)1.9 (1.4–7.7)
V/F (liters)36.4 (28.6–58.5)
  • a kel, elimination rate constant; t1/2, half-life; Tmax, time to Cmax; Cmax, maximal serum concentration; AUClast, area under the serum concentration-versus-time curve at the time of the last concentration determination; AUC0–∞, area under the serum concentration-versus-time curve from time zero to infinity; CL, clearance; V, volume of distribution; F, bioavailability (which was assumed to be 1 for purposes of analysis).

  • b Data are for 10 patients receiving pyrazinamide.