Table 2.

Quinolone-induced DNA cleavage by gyrase

CompoundRelative amt of drug required to induce 50% maximal DNA cleavage for mutanta
Ala83Ala87Ala83Ala87
Ciprofloxacin3.6 ± 0.23.9 ± 1.68.9 ± 1.8
PD01634491.4 ± 03.1 ± 0.44.3 ± 1.4
Norfloxacin4.8 ± 1.04.4 ± 0.820.5 ± 1.6
  • a Calculated as the amount of drug required to induce 50% maximal cleavage for the mutant divided by the amount required to induce 50% maximal cleavage for the WT.