Table 3.

Interference by GT160-246 with the antimicrobial activities of antibiotics

Antibiotic Concn range (μg/ml)Interferencea with activity against the following bacteria (ATCC no.):
S. aureus(29213)B. fragilis (25285)E. faecalis(29212)E. coli (25922)P. aeruginosa(27853)B. thetaiotaomicron (29741)E. lentum (43055)C. perfringens (13124)
Metronidazole0.125–16NSNSNSNS
Vancomycin0.25–32NSNSNS
Penicillin0.125–128NS
Ampicillin0.125–128NS
Oxacillin0.06–64NSNS
Amoxacillin w/clavulanic acid0.06–64NS
Clindamycin0.03–64NSNS
Cephalexin0.06–128NS
Cefuroxime0.25–64NSNSNSNS
Azithromycin0.25–64+++
Erthromycin0.125–64
Clarithromycin0.06–32NSNS
Ciprofloxacin0.002–16NS
Gatifloxacin0.004–8
Levofloxacin0.004–32
Tetracycline0.06–128
Trimethoprim-sulfonamide0.125/2.13–128/2461NS
  • a Interference was considered positive (+) if the MIC was raised by >2 dilutions in two replicate wells. −, no interference; NS, not susceptible to the indicated antibiotic (alone) at the highest concentration tested.