Table 1.

Pharmacodynamic analysis

Quinolone (MIC [mg/liter])Peak (mg/liter)AUCAUC/MIC ratioT3K (h)aSlope (±SD)95% confidence interval r2Bacterial regrowthPost-fluoroquinolone exposure MIC (mg/liter)c
LevoSparTrova
Levofloxacin (8)0.881 N/Ab 812
6.448611.4−0.279 ± 0.017−0.316 to −0.2410.95Yes3248
10.4112146.8−0.379 ± 0.034−0.452 to −0.3060.90Yes3248
63.26007511.3−0.300 ± 0.013−0.329 to −0.2720.97No812
276.02,34429314.3−0.235 ± 0.013−0.263 to −0.2080.96No812
Sparfloxacin (2)0.221N/A812
0.684N/A812
1.8241210.7−0.315 ± 0.025−0.367 to −0.2620.92Yes64816
6.8106535.9−0.370 ± 0.034−0.442 to −0.2970.90No812
17.228614312.1−0.277 ± 0.011−0.300 to −0.2530.98No812
Trovafloxacin (1)0.111N/A812
0.444N/A812
0.911118.4−0.358 ± 0.025−0.412 to −0.3040.94Yes32416
4.3565610.2−0.295 ± 0.009−0.315 to −0.2760.99No812
11.41381386.0−0.331 ± 0.030−0.395 to −0.2670.90No812
  • a T3K, time to 3-log kill.

  • b N/A, not achieved.

  • c Levo, levofloxacin; Spar, sparfloxacin; Trova, trovafloxacin.