Table 2.

MICs of GT160-246 for anaerobic organisms compared with those of metronidazole and imipenem

Microorganism (ATCC no.)MIC (μg/ml)
GT160-24MetronidazoleImipenem
Bacteroides fragilis (10619)>5,1201.00.125
Bacteroides fragilis (25285)>5,1200.50.125
Bacteroides distasonis (10618)>5,1200.50.5
Bacteroides distasonis (10566)>5,12012
Bacteroides thetaiotaomicron(10624)>5,12020.25
Bacteroides thetaiotaomicron (29741)>5,12010.25
Bacteroides ovatus (10610)>5,12010.125
Bacteroides ovatus (10600)>5,12020.25
Fusobacterium mortiferum(10494)>5,1200.250.5
Fusobacterium mortiferum (10009)>5,1200.50.5
Fusobacterium varium (10479)>5,1200.51
Fusobacterium varium (10039)>5,1200.50.5
Acidaminococcus fermentum(10351)>5,1200.250.5
Acidaminococcus fermentum (9904)>5,1200.50.25
Clostridium perfringens (10436)>5,12020.06
Clostridium perfringens (10385)>5,12020.125
Clostridium innocuum (10617)5,12012
Clostridium innocuum(10537)5,1200.1250.015a
Clostridium clostridiofonne(10616)>5,1200.252
Clostridium clostridiofonne (10588)>5,120≤0.061
Clostridium ranosum (10421)>5,12080.5
Clostridium ranosum (10329)>5,12020.25
Clostridium difficile (9311)>5,1200.254
Clostridium difficile (4973)>5,1200.254
Bifidobacterium adolescentis(539)>5,1200.50.06
Bifidobacterium bifidum(544)>5,1208≤0.015
Lactobacillus acidophilous (9804)>5,120>1288
Lactobacillus casei (9866)>5,120>1288
Eubacterium limosum (536)5,12040.25
Eubacterium contortum (537)5,12040.03
Eubacterium lentum (43055)5,1200.1250.5
Peptostreptococcus magnus (357)2,5600.50.03
Peptostreptococcus ashccharolyricus(368)5,1200.25≤0.015
Peptostreptococcus producrus (7207)5,1200.251