Table 1.

Comparative in vitro activities of telithromycin against 203 S. pneumoniae isolates

Antimicrobial agentMIC (μg/ml)a% of fully susceptible isolatesb
Range 50% 90%
Penicillin ≤0.008–4 0.06 251.7
Cefotaxime ≤0.004–1 0.01 0.5 94.0
Telithromycin ≤0.002–1 0.01 0.06NAc
Erythromycin≤0.008–>64 0.03 >64 61.0
Clindamycin≤0.008–>64 0.06 >64 68.0
Quinupristin-dalfopristin 0.06–8 1 2 69.9
Levofloxacin 0.12–8 0.5 1 99.6
  • a 50% and 90%, MICs at which 50 and 90% of isolates are inhibited, respectively.

  • b NCCLS breakpoints (18).

  • c NA, not applicable.