Table 6.

Relationships between pharmacodynamic parameters of VER-002 and the residual fungal burden of A. fumigatus in lung tissue at postmortema

Parameter compared with fungal burdenValue with inhibitory effectEmax pharmacodynamic ModelLinear regression (r)
EmaxEP50r2 (obs/pred)
Cmax2.038 ± 0.148448 ± 6320.0142 0.0436
AUC0–242.049 ± 0.1482,508 ± 2,9410.0115 0.0248
Tτ≥(3× MIC)2.180 ± 0.200119 ± 880.0298 0.0616
Clung tissue2.049 ± 0.158848 ± 1,2450.0851b0.2446
  • a Values for Emaxand EP50 are expressed as means ± standard deviations. Clung tissue, concentration of VER in lung tissue at autopsy. The equation for the pharmacodynamic model is E = Emax ∗ {1 − [C/(C + EP50)]}, whereEmax is maximum log(CFU per gram) ofA. Fumigatus in lung tissue and EP50 is the magnitude of the assessed parameter that would be associated with a 50% reduction in log(CFU per gram) in lung tissue. obs/pred, observed/predicted.

  • b P < 0.05 .