Parameter compared with fungal burden | Value with inhibitory effectE_{max} pharmacodynamic Model | Linear regression (r) | ||
---|---|---|---|---|

E_{max} | EP_{50} | r^{2} (obs/pred) | ||

C_{max} | 2.038 ± 0.148 | 448 ± 632 | 0.0142 | 0.0436 |

AUC_{0–24} | 2.049 ± 0.148 | 2,508 ± 2,941 | 0.0115 | 0.0248 |

Tτ≥(3× MIC) | 2.180 ± 0.200 | 119 ± 88 | 0.0298 | 0.0616 |

C_{lung tissue} | 2.049 ± 0.158 | 848 ± 1,245 | 0.0851^{b} | 0.2446 |

↵a Values for

*E*_{max}and EP_{50}are expressed as means ± standard deviations.*C*_{lung tissue}, concentration of VER in lung tissue at autopsy. The equation for the pharmacodynamic model is*E*=*E*_{max}∗ {1 − [*C*/(*C*+ EP_{50})]}, where*E*_{max}is maximum log(CFU per gram) of*A. Fumigatus*in lung tissue and EP_{50}is the magnitude of the assessed parameter that would be associated with a 50% reduction in log(CFU per gram) in lung tissue. obs/pred, observed/predicted.↵b P < 0.05 .