Table 2.

Nucleotide and amino acid substitutions inERG11 genes from C. albicans isolates

Patient Isolate Fluconazole MIC (μg/ml)Substitutiona
D116E F126L K128T Y132F K143R T229A G307SS405F V437I D446N F449S G450E G464S
7 412 0.5A383C
2307 >64A383C
91002 0.25
2823>64
3795>64 T376C A428G
14 580 4
2440 64G1309A
250064 G1309A
15 945 8 T348AG1349A
1619 64T348A G919A G1349A
16 3107 4 A395T
3119 >64A395T
3120>64 A395T
3184 64A395T
328164 A395T
28 5044 4G1309A G1336A
5052 64G1309A G1336A
30 5106 8G1309A
510864 G1309AG1390A
42 1691 0.25A383C
3731>64 T376C A428G
3733 64 T376CA428G
431649 0.5
3034>64
512274 16 C1214T
2257 64C1214T
233964 C1214T
59 3917 4T1346C
461764 A685G T1346C
4639 >64 A685GT1346C
64 4018 4
4380 64G1309A
  • a The base numbers are with respect to the first ATG codon of ERG11.