Table 4.

Summary of amino acid substitutions in Erg11p and gene overexpression in fluconazole-resistant C. albicansisolates compared to matched susceptible isolates

Patient Isolate Fluconazole MIC (μg/ml) Amino acid substitutions in Erg11p Gene overexpression
7 412 0.5K128T
2307>64 K128T ERG11, CDR, CDR1, andCDR2
9 1002 0.25
2823>64 ERG11, MDR1, and CDR2 ERG11
3795 >64
14 580 4
2440 64 V437I V437I, ERG11, andMDR1
2500 64 V437I V437I,ERG11, and MDR1
15 945 8D116E and G450E
1619 64 D116E and G450E ERG11 and CDR2
16 3107 4Y132F
3119 >64 Y132F MDR1
3120 >64 Y132F MDR1
3184 64Y132F CDR
3281 64 Y132F CDR
285044 4 V437I and D446N
5052 64 V437I and D446N MDR1, CDR, CDR1, andCDR2
30 5106 8 V437I
5108 64 V437I and G464S ERG11, MDRI, CDR, and CDR1
42 1691 0.25 K128T
3731 >64 F126L and K143R MDR1
3733 64 F126L and K143R MDR1
43 1649 0.5
3034 >64 MDR1, CDR, CDR1, and CDR2
51 2274 16 S405F
2257 64S405F
2339 64 S405F CDR, CDR1, and CDR2
59 3917 4 F449S
4617 64 F449S and T229A MDR1, CDR, and CDR1
4639 >64 F449S and T229A
64 4018 4
4380 64 V437ICDR, CDR1, and CDR2