Table 3.

Effect of VER on residual fungal burden in kidney tissue and dosage-related pharmacodynamic parameters in persistently neutropenic rabbits with subacute disseminated candidiasisa

Dosage groupC. albicans in kidney tissue [log(CFU/g)]Cmax (μg/ml)Cmin (μg/ml)AUC0–24 (μg · h/ml)Tτ≥MFC (h)Ckidney tissue (μg/g)
0.1 mg/kg QD5.678 ± 0.6370.655 ± 0.1190.028 ± 0.0092.283 ± 0.4430.904 ± 0.2020.166 ± 0.034
0.25 mg/kg QD2.575 ± 1.1971.412 ± 0.1550.037 ± 0.0064.390 ± 0.4733.500 ± 0.4040.360 ± 0.165
0.5 mg/kg QD0.000 ± 0.0001.951 ± 0.1220.088 ± 0.0138.251 ± 0.65811.580 ± 1.0200.700 ± 0.106
1.0 mg/kg QD0.000 ± 0.0003.290 ± 0.2160.129 ± 0.00712.466 ± 0.56816.13 ± 1.0401.333 ± 0.086
Untreated controls6.225 ± 0.479NANANANANA
  • a All parameters are provided as means ± standard errors of the means.Cmin, concentration in plasma 24 h after dosing; Ckidney tissue, concentration of VER in kidney tissue 24 h after the last of 10 daily dosages; NA, not applicable.