Table 1.

In vitro susceptibilities of 3,312 clinical isolates ofCandida spp. to posaconazole, itraconazole, and fluconazole

Organism (no. tested) and antifungal agentMIC (μg/ml)% Susceptible at MIC (μg/ml) of:
Range50%90%0.120.250.51
C. albicans(1,992)
 Posaconazole0.007–>80.030.0698989999
 Itraconazole0.007–>80.030.1294a979899
 Fluconazole0.12–>1280.250.599 (≤8)b
C. glabrata (421)
 Posaconazole0.015–>8145154680
 Itraconazole0.03–>8186a204370
 Fluconazole0.25–>12816>12842 (≤8)b
C. parapsilosis (468)
 Posaconazole0.015–20.060.1296999999
 Itraconazole0.015–20.120.2561a919999
 Fluconazole0.12–>1280.5298 (≤8)b
C. tropicalis (243)
 Posaconazole0.015–80.060.2585949699
 Itraconazole0.015–80.120.558a829498
 Fluconazole0.12–>1280.5296 (≤8)b
C. dubliniensis (70)
 Posaconazole0.015–0.250.030.0699100100100
 Itraconazole0.015–0.50.060.2589a99100100
 Fluconazole0.12–>1280.120.594 (≤8)b
C. guilliermondii (20)
 Posaconazole0.015–10.250.5357595100
 Itraconazole0.03–10.25120a5570100
 Fluconazole0.25–828100 (≤8)b
C. famata (12)
 Posaconazole0.015–10.251425883100
 Itraconazole0.06–20.5117a425892
 Fluconazole0.25–1641675 (≤8)b
C. krusei (47)
 Posaconazole0.12–0.50.50.5236100100
 Itraconazole0.12–20.512a307296
 Fluconazole8–>12832>1286 (≤8)b
C. lusitaniae (24)
 Posaconazole0.015–0.50.030.129696100100
 Itraconazole0.03–0.50.120.567a88100100
 Fluconazole0.12–812100 (≤8)b
Candidaspp. (15)c
 Posaconazole0.015–80.060.567759393
 Itraconazole0.015–80.06173a808793
 Fluconazole0.25–>1281>12880 (≤8)b
Total (3,312)
 Posaconazole0.007–>80.030.583869297
 Itraconazole0.007–>80.060.573a849095
 Fluconazole0.12–>1280.251690 (≤8)b
  • a Percent susceptible at NCCLS breakpoint for itraconazole (≤0.12 μg/ml).

  • b Percent susceptible at NCCLS breakpoint for fluconazole (≤8 μg/ml).

  • c Includes six Candida kefyr, fourCandida rugosa, two Candida lambica, and twoCandida inconspicua isolates and one Candida lipolytica isolate.