Table 1.

MICs of β-lactams for R. aquatilis clinical isolate DON-1 and reference strain CIP 103.904 and E. coli DH10B harboring recombinant plasmid pRAHN-1 and reference strain DH10B

β-Lactam(s)aMIC (μg/ml) for strain:
R. aquatilisE. coli
DON-1CIP 103.904DH10B(pRAHN-1)DH10B
Amoxicillin256256>5122
Amoxicillin + CLA2442
Ticarcillin>512>512>5121
Ticarcillin + CLA4481
Piperacillin816161
Piperacillin + TZB<1<111
Cephalothin5125122562
Cefuroxime1281282562
Cefotaxime444<0.06
Cefotaxime + CLA<0.060.06<0.06<0.06
Cefotaxime + TZB<0.06<0.06<0.06<0.06
Ceftazidime0.250.50.250.12
Ceftazidime + CLA0.120.120.12<0.06
Ceftazidime + TZB0.120.12<0.06<0.06
Ceftriaxone444<0.06
Cefepime10.50.25<0.06
Cefepime + CLA<0.060.06<0.06<0.06
Cefepime + TZB<0.06<0.06<0.06<0.06
Cefpirome144<0.06
Cefpirome + CLA<0.060.06<0.06<0.06
Cefpirome + TZB<0.06<0.06<0.06<0.06
Cefoxitin4842
Moxalactam0.250.50.250.12
Aztreonam1110.06
Meropenem0.060.06<0.06<0.06
Imipenem0.50.50.50.06
  • a CLA, clavulanic acid at a fixed concentration of 2 μg/ml; TZB, tazobactam at a fixed concentration of 4 μg/ml.