Table 2.

Levels of VER in tissue after multiple dosing in animals systemically infected with C. albicansa

Dose (mg/kg · day)Brain (μg/g)Aqueous humor (μg/ml)Vitreous humor (μg/ml)Choroid (μg/ml)Lung (μg/g)Liver (μg/g)Spleen (μg/g)Kidney (μg/g)
0.1<LLQ<LLQ<LLQ<LLQ0.851 ± 0.160.327 ± 0.050.245 ± 0.65<LLQ
0.25<LLQ<LLQ<LLQ<LLQ1.311 ± 0.150.621 ± 0.170.443 ± 0.110.360 ± 0.16
0.50.247 ± 0.02<LLQ<LLQ<LLQ2.520 ± 0.351.236 ± 0.160.892 ± 0.130.701 ± 0.10
10.415 ± 0.02<LLQ<LLQ<LLQ4.196 ± 0.462.808 ± 0.221.549 ± 0.021.332 ± 0.08
51.580 ± 0.07<LLQ0.098 ± 0.150.299 ± 0.0717.93 ± 0.9016.82 ± 0.849.820 ± 0.816.870 ± 0.65
103.907 ± 0.250.064 ± 0.0060.184 ± 0.061.469 ± 0.2132.64 ± 2.0343.76 ± 1.6221.74 ± 1.8616.92 ± 0.56
  • a Values represent the means ± standard errors of the means of six rabbits each except for the 10-mg/kg dosage cohort (three rabbits). Tissues were obtained 24 h after the last of 10 daily dosages. The LLQ of the analytical assay was <0.020 μg/ml for aqueous and vitreous humor and choroid and <0.200 μg/g for all solid tissues.