Table 5.

Effect of VER on residual fungal burden in lung tissue and dosage-related pharmacodynamic parameters in persistently neutropenic rabbits with invasive pulmonary aspergillosisa

Dosage groupA. fumigatus in lung tissue [log(CFU/g)]Cmax (μg/ml)Cmin (μg/ml)AUC0–24(μg · h/ml)Tτ≥(3× MIC) (h)Clung tissue (μg/g)
1 mg/kg QD1.919 ± 0.3623.260 ± 0.2000.171 ± 0.03313.877 ± 1.38611.21 ± 1.836.690 ± 0.925
5 mg/kg QD2.356 ± 0.31115.764 ± 0.5781.168 ± 0.27878.000 ± 9.26123.71 ± 0.2834.605 ± 4.722
10 mg/kg QD1.598 ± 0.21632.251 ± 2.2221.965 ± 0.409164.22 ± 21.2624.00 ± 0.0047.737 ± 5.637
5 mg/kg BID1.960 ± 0.25717.838 ± 2.6012.732 ± 0.522142.21 ± 21.0124.00 ± 0.0033.647 ± 4.690
20 mg/kg QD2.310 ± 0.22673.279 ± 7.0873.190 ± 0.406359.03 ± 42.3224.00 ± 0.00112.430 ± 14.421
10 mg/kg BID2.175 ± 0.24439.908 ± 3.4716.652 ± 1.476326.70 ± 39.2724.00 ± 0.0067.670 ± 2.406
Untreated controls1.768 ± 0.231NANANANANA
  • a All parameters are provided as means ± standard errors of the means.Cmin, concentration in plasma 24 h after dosing;Clung tissue, concentration of VER in lung tissue at autopsy; NA, not applicable.