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acyclovir

  • Differences in the Likelihood of Acyclovir Resistance-Associated Mutations in the Thymidine Kinase Genes of Herpes Simplex Virus 1 and Varicella-Zoster Virus
    Antiviral Agents
    Differences in the Likelihood of Acyclovir Resistance-Associated Mutations in the Thymidine Kinase Genes of Herpes Simplex Virus 1 and Varicella-Zoster Virus

    Acyclovir (ACV) resistance-associated mutations in two recombinant herpes simplex virus 1 (HSV-1) clones were compared. Recombinant HSV-1 lacking its thymidine kinase (TK) and expressing varicella-zoster virus (VZV) TK ectopically had no mutations in the VZV TK gene.

    Hikaru Fujii, Shizuko Harada, Tomoki Yoshikawa, Souichi Yamada, Natsumi Omura, Miho Shibamura, Takuya Inagaki, Hirofumi Kato, Shuetsu Fukushi, Masayuki Saijo
  • Pharmacology
    Pharmacokinetics of Acyclovir and Its Metabolites in Cerebrospinal Fluid and Systemic Circulation after Administration of High-Dose Valacyclovir in Subjects with Normal and Impaired Renal Function
    James P. Smith, Stephen Weller, Benjamin Johnson, Janet Nicotera, James M. Luther, David W. Haas
  • Antiviral Agents
    Population Pharmacokinetics of Acyclovir in Children and Young People with Malignancy after Administration of Intravenous Acyclovir or Oral Valacyclovir
    L. Zeng, C. E. Nath, E. Y. L. Blair, P. J. Shaw, K. Stephen, J. W. Earl, J. C. Coakley, A. J. McLachlan
  • Antiviral Agents
    Pharmacokinetics of Acyclovir after Intravenous Infusion of Acyclovir and after Oral Administration of Acyclovir and Its Prodrug Valacyclovir in Healthy Adult Horses
    B. Garré, K. Shebany, A. Gryspeerdt, K. Baert, K. van der Meulen, H. Nauwynck, P. Deprez, P. De Backer, S. Croubels
  • Antiviral Agents
    Thymidine Kinase Mutations Conferring Acyclovir Resistance in Herpes Simplex Type 1 Recombinant Viruses
    Yan Sergerie, Guy Boivin
  • Antiviral Agents
    Early Selection of a New UL97 Mutant with a Severe Defect of Ganciclovir Phosphorylation after Valaciclovir Prophylaxis and Short-Term Ganciclovir Therapy in a Renal Transplant Recipient
    Sébastien Hantz, Detlef Michel, Anne-Marie Fillet, Vincent Guigonis, Gaël Champier, Marie-Christine Mazeron, Albert Bensman, François Denis, Thomas Mertens, Axelle Dehee, Sophie Alain
  • Antiviral Agents
    Herpes Simplex Virus Thymidine Kinase Mutations Associated with Resistance to Acyclovir: a Site-Directed Mutagenesis Study
    E. Frobert, T. Ooka, J. C. Cortay, B. Lina, D. Thouvenot, F. Morfin
  • Antiviral Agents
    Susceptibilities of Several Clinical Varicella-Zoster Virus (VZV) Isolates and Drug-Resistant VZV Strains to Bicyclic Furano Pyrimidine Nucleosides
    Graciela Andrei, Rebecca Sienaert, Chris McGuigan, Erik De Clercq, Jan Balzarini, Robert Snoeck
  • Antiviral Agents
    Acyclovir Levels in Serum and Cerebrospinal Fluid after Oral Administration of Valacyclovir
    Jan Lycke, Clas Malmeström, Lars Ståhle
  • Antiviral Agents
    Intra- and Interindividual Variabilities of Valacyclovir Oral Bioavailability and Effect of Coadministration of an hPEPT1 Inhibitor
    Dana D. Phan, Peter Chin-Hong, Emil T. Lin, Pascale Anderle, Wolfgang Sadee, B. Joseph Guglielmo

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