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Amides

  • New Amides Containing Selenium as Potent Leishmanicidal Agents Targeting Trypanothione Reductase
    Chemistry; Biosynthesis
    New Amides Containing Selenium as Potent Leishmanicidal Agents Targeting Trypanothione Reductase

    Two new series of 28 selenocyanate and diselenide derivatives containing amide moieties were designed, synthesized, and evaluated for their leishmanicidal activity against Leishmania infantum axenic amastigotes, and selectivity was assessed in human THP-1 cells. Eleven compounds exhibited excellent leishmanicidal activity with EC50 values lower than the...

    Mikel Etxebeste-Mitxeltorena, Daniel Plano, Socorro Espuelas, Esther Moreno, Carlos Aydillo, Antonio Jiménez-Ruiz, Juan Carlos García Soriano, Carmen Sanmartín
  • Antiviral Agents
    Extinction of West Nile Virus by Favipiravir through Lethal Mutagenesis
    Estela Escribano-Romero, Nereida Jiménez de Oya, Esteban Domingo, Juan Carlos Saiz
  • Free
    Antiviral Agents
    Favipiravir Pharmacokinetics in Nonhuman Primates and Insights for Future Efficacy Studies of Hemorrhagic Fever Viruses
    Vincent Madelain, Jérémie Guedj, France Mentré, Thi Huyen Tram Nguyen, Frédéric Jacquot, Lisa Oestereich, Takumi Kadota, Koichi Yamada, Anne-Marie Taburet, Xavier de Lamballerie, Hervé Raoul
  • Free
    Antiviral Agents
    In Vitro Antiviral Activity of Favipiravir (T-705) against Drug-Resistant Influenza and 2009 A(H1N1) Viruses
    Katrina Sleeman, Vasiliy P. Mishin, Varough M. Deyde, Yousuke Furuta, Alexander I. Klimov, Larisa V. Gubareva
  • Antiviral Agents
    Effects of the Combination of Favipiravir (T-705) and Oseltamivir on Influenza A Virus Infections in Mice
    Donald F. Smee, Brett L. Hurst, Min-Hui Wong, Kevin W. Bailey, E. Bart Tarbet, John D. Morrey, Yousuke Furuta
  • Antiviral Agents
    Activity of T-705 in a Hamster Model of Yellow Fever Virus Infection in Comparison with That of a Chemically Related Compound, T-1106
    Justin G. Julander, Kristiina Shafer, Donald F. Smee, John D. Morrey, Yousuke Furuta
  • Mechanisms of Resistance
    Genetic Analysis of Fenhexamid-Resistant Field Isolates of the Phytopathogenic Fungus Botrytis cinerea
    Sabine Fillinger, Pierre Leroux, Christiane Auclair, Christian Barreau, Charbel Al Hajj, Danièle Debieu
  • Antiviral Agents
    In Vitro and In Vivo Activities of T-705 against Arenavirus and Bunyavirus Infections
    Brian B. Gowen, Min-Hui Wong, Kie-Hoon Jung, Andrew B. Sanders, Michelle Mendenhall, Kevin W. Bailey, Yousuke Furuta, Robert W. Sidwell
  • Antiviral Agents
    Activity of T-1106 in a Hamster Model of Yellow Fever Virus Infection
    Justin G. Julander, Yousuke Furuta, Kristiina Shafer, Robert W. Sidwell
  • Antiviral Agents
    Efficacy of Orally Administered T-705 on Lethal Avian Influenza A (H5N1) Virus Infections in Mice
    Robert W. Sidwell, Dale L. Barnard, Craig W. Day, Donald F. Smee, Kevin W. Bailey, Min-Hui Wong, John D. Morrey, Yousuke Furuta

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