AMR

  • Pharmacodynamics of Tebipenem: New Options for Oral Treatment of Multidrug-Resistant Gram-Negative Infections
    Pharmacology
    Pharmacodynamics of Tebipenem: New Options for Oral Treatment of Multidrug-Resistant Gram-Negative Infections

    Tebipenem pivoxil HBr (TBPM-PI-HBr) is a novel orally bioavailable carbapenem. The active moiety is tebipenem. Tebipenem pivoxil is licensed for use in Japan in children with ear, nose, and throat infections and respiratory infections. The HBr salt was designed to improve drug substance and drug product properties, including stability. TBPM-PI-HBr is now being developed as an agent for the treatment of complicated urinary tract...

    Laura McEntee, Adam Johnson, Nicola Farrington, Jennifer Unsworth, Aaron Dane, Akash Jain, Nicole Cotroneo, Ian Critchley, David Melnick, Thomas Parr, Paul G. Ambrose, Shampa Das, William Hope
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