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anidulafungin

  • Anidulafungin Susceptibility Testing of <span class="named-content genus-species" id="named-content-1">Candida glabrata</span> Isolates from Blood Cultures by the MALDI Biotyper Antibiotic (Antifungal) Susceptibility Test Rapid Assay
    Susceptibility
    Anidulafungin Susceptibility Testing of Candida glabrata Isolates from Blood Cultures by the MALDI Biotyper Antibiotic (Antifungal) Susceptibility Test Rapid Assay

    Echinocandins are the recommended first-line antifungals for treatment of invasive candidiasis. The increasing number of Candida glabrata strains resistant against echinocandins is an emerging health care concern. The rapid detection of resistant C. glabrata isolates is an urgent requirement for...

    Mansoureh Vatanshenassan, Amir Arastehfar, Teun Boekhout, Judith Berman, Cornelia Lass-Flörl, Katrin Sparbier, Markus Kostrzewa
  • Echinocandins for the Treatment of Invasive Aspergillosis: from Laboratory to Bedside
    Minireview
    Echinocandins for the Treatment of Invasive Aspergillosis: from Laboratory to Bedside

    Echinocandins (caspofungin, micafungin, anidulafungin), targeting β-1,3-glucan synthesis of the cell wall, represent one of the three currently available antifungal drug classes for the treatment of invasive fungal infections. Despite their limited antifungal activity against Aspergillus spp., echinocandins are considered an alternative option for the treatment of invasive aspergillosis (IA).

    Marion Aruanno, Emmanouil Glampedakis, Frédéric Lamoth
  • Population Pharmacokinetics of Anidulafungin in Critically Ill Patients
    Clinical Therapeutics
    Population Pharmacokinetics of Anidulafungin in Critically Ill Patients

    A two-compartment pharmacokinetic (PK) population model of anidulafungin was fitted to PK data from 23 critically ill patients (age, 65 years [range, 28 to 81 years]; total body weight [TBW], 75 kg [range, 54 to 168 kg]). TBW was associated with clearance and incorporated into a final population PK model.

    S. Luque, W. Hope, N. Campillo, R. Muñoz-Bermúdez, L. Sorli, J. Barceló-Vidal, E. González-Colominas, F. Alvarez-Lerma, J. R. Masclans, M. Montero, J. P. Horcajada, S. Grau
  • Spontaneous Mutational Frequency and <em>FKS</em> Mutation Rates Vary by Echinocandin Agent against <em>Candida glabrata</em>
    Mechanisms of Resistance
    Spontaneous Mutational Frequency and FKS Mutation Rates Vary by Echinocandin Agent against Candida glabrata

    Echinocandins are front-line agents for treatment of invasive candidiasis. There are no reported agent-specific differences in Candida mutational frequency of resistance or propensity to develop FKS mutations.

    Ryan K. Shields, Ellen G. Kline, Kelley R. Healey, Milena Kordalewska, David S. Perlin, M. Hong Nguyen, Cornelius J. Clancy
  • Pharmacology
    Pharmacokinetics of Anidulafungin in Obese and Normal-Weight Adults
    Roeland E. Wasmann, Rob ter Heine, Eric P. van Dongen, David M. Burger, Vincent J. Lempers, Catherijne A. Knibbe, Roger J. Brüggemann
  • Mechanisms of Resistance
    Understanding Echinocandin Resistance in the Emerging Pathogen Candida auris
    Milena Kordalewska, Annie Lee, Steven Park, Indira Berrio, Anuradha Chowdhary, Yanan Zhao, David S. Perlin
  • Open Access
    Mechanisms of Action: Physiological Effects
    Gene Expression of Pneumocystis murina after Treatment with Anidulafungin Results in Strong Signals for Sexual Reproduction, Cell Wall Integrity, and Cell Cycle Arrest, Indicating a Requirement for Ascus Formation for Proliferation
    Melanie T. Cushion, Alan Ashbaugh, Keeley Hendrix, Michael J. Linke, Nikeya Tisdale, Steven G. Sayson, Aleksey Porollo
  • Susceptibility
    A New Marker of Echinocandin Activity in an In Vitro Pharmacokinetic/Pharmacodynamic Model Correlates with an Animal Model of Aspergillus fumigatus Infection
    Joseph Meletiadis, Maria Siopi, Athanassios Tsakris, Johan W. Mouton, Spyros Pournaras
  • Susceptibility
    In Vitro Activity of Posaconazole against Talaromyces marneffei by Broth Microdilution and Etest Methods and Comparison to Itraconazole, Voriconazole, and Anidulafungin
    Susanna K. P. Lau, George C. S. Lo, Clare S. K. Lam, Wang-Ngai Chow, Antonio H. Y. Ngan, Alan K. L. Wu, Dominic N. C. Tsang, Cindy W. S. Tse, Tak-Lun Que, Bone S. F. Tang, Patrick C. Y. Woo
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