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antibiotic prophylaxis

  • Pharmacokinetic Model for Cefuroxime Dosing during Cardiac Surgery under Cardiopulmonary Bypass
    Pharmacology
    Pharmacokinetic Model for Cefuroxime Dosing during Cardiac Surgery under Cardiopulmonary Bypass

    Cefuroxime (CXM) is an antibiotic recommended for surgical site infection prevention in cardiac surgery. However, the dosing regimens commonly used do not sustain therapeutic concentrations throughout surgery. The aim of this study was to conduct a population analysis of CXM pharmacokinetics (PK), and to propose an optimized dosing regimen. Adult patients undergoing cardiac surgery under cardiopulmonary bypass (CPB) received a 1,500 mg...

    J. Lanoiselée, P. J. Zufferey, S. Hodin, N. Tamisier, L. Gergelé, J. C. Palao, S. Campisi, S. Molliex, J. Morel, X. Delavenne, E. Ollier
  • Observational, Prospective Single-Center Study of Antibiotic Prophylaxis with High-Dose Cefoxitin in Bariatric Surgery
    Pharmacology
    Observational, Prospective Single-Center Study of Antibiotic Prophylaxis with High-Dose Cefoxitin in Bariatric Surgery

    The optimal dose of cefoxitin for antibiotic prophylaxis in obese patients remains uncertain. We evaluated the adequacy of a 4-g dosing regimen of cefoxitin against the most common pathogens that infect patients undergoing bariatric surgery. This observational prospective study included obese patients who required bariatric surgery and a 4-g dose of cefoxitin as an antibiotic prophylaxis. Serum concentrations were measured during...

    Thibaut Belveyre, Philippe Guerci, Elise Pape, Nathalie Thilly, Kossar Hosseini, Laurent Brunaud, Nicolas Gambier, Claude Meistelman, Marie-Reine Losser, Julien Birckener, Julien Scala-Bertola, Emmanuel Novy
  • Epidemiology and Surveillance
    Incidences of Pseudomonas aeruginosa-Associated Ventilator-Associated Pneumonia within Studies of Respiratory Tract Applications of Polymyxin: Testing the Stoutenbeek Concurrency Postulates
    James C. Hurley
  • Experimental Therapeutics
    Population Pharmacokinetic Model-Based Evaluation of Standard Dosing Regimens for Cefuroxime Used in Coronary Artery Bypass Graft Surgery with Cardiopulmonary Bypass
    Saeed A. Alqahtani, Abdullah S. Alsultan, Hussain M. Alqattan, Ahmed Eldemerdash, Turki B. Albacker
  • Pharmacology
    Oral Tobramycin Prophylaxis Prior to Colorectal Surgery Is Not Associated with Systemic Uptake
    T. Mulder, M. F. Q. Kluytmans-van den Bergh, R. M. P. H. Crolla, A. A. M. Ermens, J. Romme, N. E. van‘t Veer, J. A. J. W. Kluytmans
  • Epidemiology and Surveillance
    Antimicrobial Resistance Risks of Cholera Prophylaxis for United Nations Peacekeepers
    Amber Kunkel, Joseph A. Lewnard, Virginia E. Pitzer, Ted Cohen
  • Epidemiology and Surveillance
    Antibiotic Prophylaxis Is Associated with Subsequent Resistant Infections in Children with an Initial Extended-Spectrum-Cephalosporin-Resistant Enterobacteriaceae Infection
    Sibani Das, Amanda L. Adler, Arianna Miles-Jay, Matthew P. Kronman, Xuan Qin, Scott J. Weissman, Carey-Ann D. Burnham, Alexis Elward, Jason G. Newland, Rangaraj Selvarangan, Kaede V. Sullivan, Theoklis Zaoutis, Danielle M. Zerr
  • Clinical Therapeutics
    Interrupted Time Series Analysis of Vancomycin Compared to Cefuroxime for Surgical Prophylaxis in Patients Undergoing Cardiac Surgery
    K. W. Garey, D. Lai, T. K. Dao-Tran, L. O. Gentry, L. Y. Hwang, B. R. Davis
  • Experimental Therapeutics
    Single-Dose Oral Amoxicillin or Linezolid for Prophylaxis of Experimental Endocarditis Due to Vancomycin-Susceptible and Vancomycin-Resistant Enterococcus faecalis
    Philippe Moreillon, Walter R. Wilson, Roland Leclercq, José M. Entenza
  • Experimental Therapeutics
    Determination of Antibiotic Efficacy against Bacillus anthracis in a Mouse Aerosol Challenge Model
    Henry S. Heine, Jennifer Bassett, Lynda Miller, Justin M. Hartings, Bruce E. Ivins, M. Louise Pitt, David Fritz, Sarah L. Norris, W. Russell Byrne

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