antibiotic prophylaxis
PharmacologyPharmacokinetic Model for Cefuroxime Dosing during Cardiac Surgery under Cardiopulmonary BypassCefuroxime (CXM) is an antibiotic recommended for surgical site infection prevention in cardiac surgery. However, the dosing regimens commonly used do not sustain therapeutic concentrations throughout surgery. The aim of this study was to conduct a population analysis of CXM pharmacokinetics (PK), and to propose an optimized dosing regimen. Adult patients undergoing cardiac surgery under cardiopulmonary bypass (CPB) received a 1,500 mg...
PharmacologyObservational, Prospective Single-Center Study of Antibiotic Prophylaxis with High-Dose Cefoxitin in Bariatric SurgeryThe optimal dose of cefoxitin for antibiotic prophylaxis in obese patients remains uncertain. We evaluated the adequacy of a 4-g dosing regimen of cefoxitin against the most common pathogens that infect patients undergoing bariatric surgery. This observational prospective study included obese patients who required bariatric surgery and a 4-g dose of cefoxitin as an antibiotic prophylaxis. Serum concentrations were measured during...
- Epidemiology and SurveillanceAntimicrobial Resistance Risks of Cholera Prophylaxis for United Nations Peacekeepers
- Experimental TherapeuticsDetermination of Antibiotic Efficacy against Bacillus anthracis in a Mouse Aerosol Challenge Model