Antibodies, Monoclonal

Open Access

Experimental Therapeutics
Multiple Modes of Action of a Monoclonal Antibody against Multidrug-Resistant Escherichia coli Sequence Type 131-H30
Luis M. Guachalla, Katharina Hartl, Cecília Varga, Lukas Stulik, Irina Mirkina, Stefan Malafa, Eszter Nagy, Gábor Nagy, Valéria Szijártó
Antiviral Agents
Phase 2 Randomized Trial of the Safety and Efficacy of MHAA4549A, a Broadly Neutralizing Monoclonal Antibody, in a Human Influenza A Virus Challenge Model
Jacqueline M. McBride, Jeremy J. Lim, Tracy Burgess, Rong Deng, Michael A. Derby, Mauricio Maia, Priscilla Horn, Omer Siddiqui, Daniel Sheinson, Haiyin Chen-Harris, Elizabeth M. Newton, Dimitri Fillos, Denise Nazzal, Carrie M. Rosenberger, Maikke B. Ohlson, Rob Lambkin-Williams, Hosnieh Fathi, Jeffrey M. Harris, Jorge A. Tavel
Experimental Therapeutics
A Human Biofilm-Disrupting Monoclonal Antibody Potentiates Antibiotic Efficacy in Rodent Models of both Staphylococcus aureus and Acinetobacter baumannii Infections
Yan Q. Xiong, Angeles Estellés, L. Li, W. Abdelhady, R. Gonzales, Arnold S. Bayer, Edgar Tenorio, Anton Leighton, Stefan Ryser, Lawrence M. Kauvar
Open Access

Experimental Therapeutics
Multimechanistic Monoclonal Antibodies (MAbs) Targeting Staphylococcus aureus Alpha-Toxin and Clumping Factor A: Activity and Efficacy Comparisons of a MAb Combination and an Engineered Bispecific Antibody Approach
C. Tkaczyk, S. Kasturirangan, A. Minola, O. Jones-Nelson, V. Gunter, Y. Y. Shi, K. Rosenthal, V. Aleti, E. Semenova, P. Warrener, D. Tabor, C. K. Stover, D. Corti, G. Rainey, B. R. Sellman
Pharmacology
Pharmacokinetics and Preliminary Safety of Pod-Intravaginal Rings Delivering the Monoclonal Antibody VRC01-N for HIV Prophylaxis in a Macaque Model
Chunxia Zhao, Manjula Gunawardana, Francois Villinger, Marc M. Baum, Mariana Remedios-Chan, Thomas R. Moench, Larry Zeitlin, Kevin J. Whaley, Ognian Bohorov, Thomas J. Smith, Deborah J. Anderson, John A. Moss
Open Access

Antiviral Agents
Safety, Tolerability, and Pharmacokinetics of MEDI8897, the Respiratory Syncytial Virus Prefusion F-Targeting Monoclonal Antibody with an Extended Half-Life, in Healthy Adults
M. Pamela Griffin, Anis A. Khan, Mark T. Esser, Kathryn Jensen, Therese Takas, Martin K. Kankam, Tonya Villafana, Filip Dubovsky
Antiviral Agents
Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial of RG7667, a Combination Monoclonal Antibody, for Prevention of Cytomegalovirus Infection in High-Risk Kidney Transplant Recipients
Julie H. Ishida, Anita Patel, Aneesh K. Mehta, Philippe Gatault, Jacqueline M. McBride, Tracy Burgess, Michael A. Derby, David R. Snydman, Brinda Emu, Becket Feierbach, Ashley E. Fouts, Mauricio Maia, Rong Deng, Carrie M. Rosenberger, Lynn A. Gennaro, Natalee S. Striano, X. Charlene Liao, Jorge A. Tavel
Open Access

Clinical Therapeutics
Safety, Tolerability, and Pharmacokinetics of MEDI4893, an Investigational, Extended-Half-Life, Anti-Staphylococcus aureus Alpha-Toxin Human Monoclonal Antibody, in Healthy Adults
Xiang-Qing Yu, Gabriel J. Robbie, Yuling Wu, Mark T. Esser, Kathryn Jensen, Howard I. Schwartz, Terramika Bellamy, Martha Hernandez-Illas, Hasan S. Jafri
Antiviral Agents
Phase 2a Study of the CCR5 Monoclonal Antibody PRO 140 Administered Intravenously to HIV-Infected Adults
Jeffrey M. Jacobson, Jacob P. Lalezari, Melanie A. Thompson, Carl J. Fichtenbaum, Michael S. Saag, Barry S. Zingman, Paul D'Ambrosio, Nancy Stambler, Yakov Rotshteyn, Andre J. Marozsan, Paul J. Maddon, Stephen A. Morris, William C. Olson
Experimental Therapeutics
Preclinical In Vitro and In Vivo Characterization of the Fully Human Monoclonal IgM Antibody KBPA101 Specific for Pseudomonas aeruginosa Serotype IATS-O11
Michael P. Horn, Adrian W. Zuercher, Martin A. Imboden, Michael P. Rudolf, Hedvika Lazar, Hong Wu, Niels Hoiby, Stefanie C. Fas, Alois B. Lang

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Antibodies, Monoclonal

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