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antifungal resistance

  • Correlation of <em>Trichosporon asahii</em> Genotypes with Anatomical Sites and Antifungal Susceptibility Profiles: Data Analyses from 284 Isolates Collected in the Last 22 Years across 24 Medical Centers
    Editor's Pick Susceptibility
    Correlation of Trichosporon asahii Genotypes with Anatomical Sites and Antifungal Susceptibility Profiles: Data Analyses from 284 Isolates Collected in the Last 22 Years across 24 Medical Centers

    Trichosporon asahii is an opportunistic fungal pathogen that can cause severe infections with high mortality rates. Azole derivatives are the best-targeted therapy for T. asahii invasive infections, but azole-resistant isolates have been reported.

    Elaine Cristina Francisco, João N. de Almeida Junior, Flávio Queiroz-Telles, Valério Rodrigues Aquino, Ana Verena A. Mendes, Marcio de Oliveira Silva, Paulo de Tarso O. e Castro, Thais Guimarães, Vinicius Ponzio, Rosane C. Hahn, Guilherme M. Chaves, Arnaldo L. Colombo
  • Experimental Evolution Identifies Adaptive Aneuploidy as a Mechanism of Fluconazole Resistance in <span class="named-content genus-species" id="named-content-1">Candida auris</span>
    Mechanisms of Resistance
    Experimental Evolution Identifies Adaptive Aneuploidy as a Mechanism of Fluconazole Resistance in Candida auris

    Candida auris is a newly emerging fungal pathogen of humans and has attracted considerable attention from both the clinical and basic research communities. Clinical isolates of C. auris are often resistant to one or more antifungal agents. To explore how antifungal resistance develops, we performed...

    Jian Bing, Tianren Hu, Qiushi Zheng, José F. Muñoz, Christina A. Cuomo, Guanghua Huang
  • Open Access
    New Data on the <em>In Vitro</em> Activity of Fenticonazole against Fluconazole-Resistant <em>Candida</em> Species
    Letter to the Editor
    New Data on the In Vitro Activity of Fenticonazole against Fluconazole-Resistant Candida Species
    Margherita Cacaci, Giulia Menchinelli, Riccardo Torelli, Dominique Sanglard, Maurizio Sanguinetti, Brunella Posteraro
  • Antifungal Susceptibility Profiles and Drug Resistance Mechanisms of Clinical <span class="named-content genus-species" id="named-content-1">Lomentospora prolificans</span> Isolates
    Susceptibility
    Antifungal Susceptibility Profiles and Drug Resistance Mechanisms of Clinical Lomentospora prolificans Isolates

    Lomentospora prolificans is an opportunistic fungal pathogen with low susceptibility to current antifungal drugs. Here, we tested the in vitro susceptibility of 8 drugs against 42 clinical L. prolificans isolates. All isolates showed high MICs to voriconazole (MIC90>16 μg/ml...

    Yongqin Wu, Nina Grossman, Marissa Totten, Warda Memon, Anna Fitzgerald, Chunmei Ying, Sean X. Zhang
  • Antifungal Susceptibility of Clinical Yeast Isolates from a Large Canadian Reference Laboratory and Application of Whole-Genome Sequence Analysis To Elucidate Mechanisms of Acquired Resistance
    Epidemiology and Surveillance
    Antifungal Susceptibility of Clinical Yeast Isolates from a Large Canadian Reference Laboratory and Application of Whole-Genome Sequence Analysis To Elucidate Mechanisms of Acquired Resistance

    To understand the epidemiology and susceptibility patterns of yeast infections in Ontario, Canada, we examined 4,715 clinical yeast isolates submitted to our laboratory for antifungal susceptibility testing from 2014 to 2018. Candida albicans was the most frequently submitted species (43.0%), followed by C...

    Lisa R. McTaggart, Ana Cabrera, Kirby Cronin, Julianne V. Kus
  • Species Distribution and Comparison between EUCAST and Gradient Concentration Strips Methods for Antifungal Susceptibility Testing of 112 <em>Aspergillus</em> Section <em>Nigri</em> Isolates
    Susceptibility
    Species Distribution and Comparison between EUCAST and Gradient Concentration Strips Methods for Antifungal Susceptibility Testing of 112 Aspergillus Section Nigri Isolates

    Aspergillus niger, the third species responsible for invasive aspergillosis, has been considered as a homogeneous species until DNA-based identification uncovered many cryptic species. These species have been recently reclassified into the Aspergillus section Nigri. However, little is yet known among the section Nigri about the species...

    B. Carrara, R. Richards, S. Imbert, F. Morio, M. Sasso, N. Zahr, A. C. Normand, P. Le Pape, L. Lachaud, S. Ranque, D. Maubon, R. Piarroux, A. Fekkar
  • Rezafungin <em>In Vitro</em> Activity against Contemporary Nordic Clinical <em>Candida</em> Isolates and <em>Candida auris</em> Determined by the EUCAST Reference Method
    Editor's Pick Susceptibility
    Rezafungin In Vitro Activity against Contemporary Nordic Clinical Candida Isolates and Candida auris Determined by the EUCAST Reference Method

    Rezafungin (formerly CD101) is a novel echinocandin in clinical development. EUCAST epidemiological cutoff values (ECOFFs) have not yet been established. We determined the in vitro activity of rezafungin and comparators against 1,293 Nordic yeast isolates and 122 Indian Candida auris isolates and established single-center wild-type upper limits (WT-UL). The...

    Marie Helleberg, Karin Meinike Jørgensen, Rasmus Krøger Hare, Raluca Datcu, Anuradha Chowdhary, Maiken Cavling Arendrup
  • MIC and Upper Limit of Wild-Type Distribution for 13 Antifungal Agents against a <span class="named-content genus-species" id="named-content-1">Trichophyton mentagrophytes</span>-<span class="named-content genus-species" id="named-content-2">Trichophyton interdigitale</span> Complex of Indian Origin
    Susceptibility
    MIC and Upper Limit of Wild-Type Distribution for 13 Antifungal Agents against a Trichophyton mentagrophytes-Trichophyton interdigitale Complex of Indian Origin

    Dermatophytosis due to the Trichophyton mentagrophytes-Trichophyton interdigitale complex is being increasingly reported across India. Reports of therapeutic failure have surfaced recently, but there are no clinical break points (CBP) or epidemiological cutoffs (ECVs) available to guide the treatment of dermatophytosis. In this study, a total of 498 isolates of the...

    Dipika Shaw, Shreya Singh, Sunil Dogra, Jyothi Jayaraman, Ramesh Bhat, Saumya Panda, Arunaloke Chakrabarti, Nishat Anjum, Aruna Chowdappa, Mahantesh Nagamoti, Umesh Varshney, Hari Pankaj Vanam, Jayanthi Savio, Meryl Antony, Shivaprakash M. Rudramurthy
  • Inhibiting Fungal Echinocandin Resistance by Small-Molecule Disruption of Geranylgeranyltransferase Type I Activity
    Experimental Therapeutics
    Inhibiting Fungal Echinocandin Resistance by Small-Molecule Disruption of Geranylgeranyltransferase Type I Activity

    Echinocandin resistance in Candida is a great concern, as the echinocandin drugs are recommended as first-line therapy for patients with invasive candidiasis. However, therapeutic efforts to thwart echinocandin resistance have been hampered by a lack of fungal specific drug targets.

    Qiangqiang Sun, Kang Xiong, Yuncong Yuan, Jing Yu, Lianjuan Yang, Chao Shen, Chang Su, Yang Lu
  • Detection of <span class="named-content genus-species" id="named-content-1">Candida auris</span> Antifungal Drug Resistance Markers Directly from Clinical Skin Swabs
    Mechanisms of Resistance
    Detection of Candida auris Antifungal Drug Resistance Markers Directly from Clinical Skin Swabs

    Accurate and rapid assessment of Candida auris antifungal drug resistance is crucial for effective infection prevention and control actions, as well as for patient management. Here, performance of a molecular diagnostic platform, enabling rapid identification of FKS1 and ERG11 mutations conferring echinocandin and azole resistance, respectively, was...

    Milena Kordalewska, Annie Lee, Yanan Zhao, David S. Perlin

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