antimicrobial
Editor's Pick Experimental TherapeuticsLysocins: Bioengineered Antimicrobials That Deliver Lysins across the Outer Membrane of Gram-Negative BacteriaThe prevalence of multidrug-resistant Pseudomonas aeruginosa has stimulated development of alternative therapeutics. Bacteriophage peptidoglycan hydrolases, termed lysins, represent an emerging antimicrobial option for targeting Gram-positive bacteria.
SusceptibilityAntibacterial Activity of Lefamulin against Pathogens Most Commonly Causing Community-Acquired Bacterial Pneumonia: SENTRY Antimicrobial Surveillance Program (2015–2016)Lefamulin, the first semisynthetic pleuromutilin antibacterial for intravenous and oral treatment of community-acquired bacterial pneumonia (CABP), and comparators were evaluated for in vitro activity against a global collection of pathogens commonly causing CABP (n = 8595) from the 2015 and 2016 SENTRY Antimicrobial Surveillance Program. Lefamulin was highly active against the pathogens...
- Mechanisms of Action: Physiological EffectsThailandamide, a Fatty Acid Synthesis Antibiotic That Is Coexpressed with a Resistant Target Gene
Microbes encode many uncharacterized gene clusters that may produce antibiotics and other bioactive small molecules. Methods for activating these genes are needed to explore their biosynthetic potential.
- Experimental TherapeuticsAntimicrobial Activity of Ibuprofen against Cystic Fibrosis-Associated Gram-Negative Pathogens
- Mechanisms of ResistanceA Novel 6-Benzyl Ether Benzoxaborole Is Active against Mycobacterium tuberculosis In Vitro
- Mechanisms of ResistanceImplications of Antimicrobial Combinations in Complex Wound Biofilms Containing Fungi
- MinireviewAntimicrobial Effects of Antipyretics