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antimicrobial activity

  • Open Access
    <em>In Vitro</em> Activity of Cefiderocol, a Siderophore Cephalosporin, against Multidrug-Resistant Gram-Negative Bacteria
    Susceptibility
    In Vitro Activity of Cefiderocol, a Siderophore Cephalosporin, against Multidrug-Resistant Gram-Negative Bacteria

    Cefiderocol is a parenteral siderophore cephalosporin with a catechol-containing 3′ substituent. We evaluated its MICs against Gram-negative bacteria, using iron-depleted Mueller-Hinton broth. The panel comprised 305 isolates of Enterobacterales, 111 of Pseudomonas aeruginosa, and 99 of ...

    Shazad Mushtaq, Zahra Sadouki, Anna Vickers, David M. Livermore, Neil Woodford
  • Novel Peptide from Commensal <span class="named-content genus-species" id="named-content-1">Staphylococcus simulans</span> Blocks Methicillin-Resistant <span class="named-content genus-species" id="named-content-2">Staphylococcus aureus</span> Quorum Sensing and Protects Host Skin from Damage
    Editor's Pick Mechanisms of Action: Physiological Effects
    Novel Peptide from Commensal Staphylococcus simulans Blocks Methicillin-Resistant Staphylococcus aureus Quorum Sensing and Protects Host Skin from Damage

    Recent studies highlight the abundance of commensal coagulase-negative staphylococci (CoNS) on healthy skin. Evidence suggests that CoNS actively shape the skin immunological and microbial milieu to resist colonization or infection by opportunistic pathogens, including methicillin-resistant...

    Morgan M. Brown, Jakub M. Kwiecinski, Luis Mejia Cruz, Ali Shahbandi, Daniel A. Todd, Nadja B. Cech, Alexander R. Horswill
  • Investigating the Effects of Osmolytes and Environmental pH on Bacterial Persisters
    Susceptibility
    Investigating the Effects of Osmolytes and Environmental pH on Bacterial Persisters

    Bacterial persisters are phenotypic variants that temporarily demonstrate an extraordinary tolerance toward antibiotics. Persisters have been linked to the recalcitrance of biofilm-related infections; hence, a complete understanding of their physiology can lead to improvement of therapeutic strategies for such infections. Mechanisms pertaining to persister formation are thought to be associated with stress response pathways triggered by...

    Prashant Karki, Sayed Golam Mohiuddin, Pouria Kavousi, Mehmet A. Orman
  • Antimicrobial Activity of Exebacase (Lysin CF-301) against the Most Common Causes of Infective Endocarditis
    Experimental Therapeutics
    Antimicrobial Activity of Exebacase (Lysin CF-301) against the Most Common Causes of Infective Endocarditis

    Exebacase, a recombinantly produced lysin (cell wall hydrolase), and comparator antibiotics were tested by the broth microdilution method against strain sets of Staphylococcus and Streptococcus spp., which are the most common causes of infective endocarditis in humans. Exebacase was active against all Staphylococcus spp. tested, including S. aureus...

    Aubrey Watson, Jun Taek Oh, Karen Sauve, Patricia A. Bradford, Cara Cassino, Raymond Schuch
  • Efficacy of Aerosolized Rifaximin versus Tobramycin for Treatment of <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> Pneumonia in Mice
    Experimental Therapeutics
    Efficacy of Aerosolized Rifaximin versus Tobramycin for Treatment of Pseudomonas aeruginosa Pneumonia in Mice

    Pseudomonas aeruginosa is a Gram-negative opportunistic bacterial pathogen that can cause chronic lung infections in patients with cystic fibrosis (CF). The current preferred treatment for CF lung infections includes inhaled tobramycin (TOB); however, studies suggest TOB cannot effectively inhibit biofilm formation.

    Brandon D. Kirby, Roy Al Ahmar, T. Ryan Withers, Meagan E. Valentine, Monica Valentovic, Timothy E. Long, James R. Gaskins, Hongwei D. Yu
  • Open Access
    <em>In Vitro</em> Activity of a Novel Glycopolymer against Biofilms of <span class="named-content genus-species" id="named-content-1">Burkholderia cepacia</span> Complex Cystic Fibrosis Clinical Isolates
    Mechanisms of Resistance
    In Vitro Activity of a Novel Glycopolymer against Biofilms of Burkholderia cepacia Complex Cystic Fibrosis Clinical Isolates

    Burkholderia cepacia complex (Bcc) lung infections in cystic fibrosis (CF) patients are often associated with a steady decline in lung function and death. The formation of biofilms and inherent multidrug resistance are virulence factors associated with Bcc infection and contribute to increased risk of mortality in CF patients.

    Vidya P. Narayanaswamy, Andrew P. Duncan, John J. LiPuma, William P. Wiesmann, Shenda M. Baker, Stacy M. Townsend
  • Identifying Vancomycin as an Effective Antibiotic for Killing <span class="named-content genus-species" id="named-content-1">Borrelia burgdorferi</span>
    Experimental Therapeutics
    Identifying Vancomycin as an Effective Antibiotic for Killing Borrelia burgdorferi

    Borrelia burgdorferi is the causative agent of Lyme borreliosis. Antibiotic therapy of early acute infection is effective for most patients, but 10 to 20% go on to develop posttreatment Lyme disease syndrome (PTLDS).

    Xiaoqian Wu, Bijaya Sharma, Samantha Niles, Kathleen O'Connor, Rebecca Schilling, Nicole Matluck, Anthony D'Onofrio, Linden T. Hu, Kim Lewis
  • Susceptibility
    In Vitro Susceptibility of Neisseria gonorrhoeae Strains to Mupirocin, an Antibiotic Reformulated for Parenteral Administration in Nanoliposomes
    Ahuva Cern, Kristie L. Connolly, Ann E. Jerse, Yechezkel Barenholz
  • Experimental Therapeutics
    Prostaglandin E2 Receptor Antagonist with Antimicrobial Activity against Methicillin-Resistant Staphylococcus aureus
    Mélanie A. C. Ikeh, Paul L. Fidel, Mairi C. Noverr
  • Mechanisms of Resistance
    The Global Regulatory Cyclic AMP Receptor Protein (CRP) Controls Multifactorial Fluoroquinolone Susceptibility in Salmonella enterica Serovar Typhimurium
    Stefani C. Kary, Joshua R. K. Yoneda, Stephen C. Olshefsky, Laura A. Stewart, Steven B. West, Andrew D. S. Cameron

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