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antimicrobial stewardship

  • Trends in and Predictors of Carbapenem Consumption across North American Hospitals: Results from a Multicenter Survey by the MAD-ID Research Network
    Epidemiology and Surveillance
    Trends in and Predictors of Carbapenem Consumption across North American Hospitals: Results from a Multicenter Survey by the MAD-ID Research Network

    We sought to define trends in and predictors of carbapenem consumption across community, teaching, and university-affiliated hospitals in the United States and Canada. We conducted a retrospective multicenter survey of carbapenem and broad-spectrum noncarbapenem beta-lactam consumption between January 2011 and December 2013.

    Nathaniel J. Rhodes, Jamie L. Wagner, Susan L. Davis, John A. Bosso, Debra A. Goff, Michael J. Rybak, Marc H. Scheetz, on behalf of the MAD-ID Research Network
  • Geographic Mapping of <span class="named-content genus-species" id="named-content-1">Escherichia coli</span> Susceptibility To Develop a Novel Clinical Decision Support Tool
    Epidemiology and Surveillance
    Geographic Mapping of Escherichia coli Susceptibility To Develop a Novel Clinical Decision Support Tool

    Antimicrobial resistance (AMR) varies regionally. This study longitudinally maps Escherichia coli susceptibility leveraging Wisconsin antibiograms (n = 202) collected from 2009, 2013, and 2015 to inform the development of a novel clinical decision support tool.

    Laurel Legenza, Susanne Barnett, James P. Lacy, Codie See, Natalee Desotell, Andrea Eibergen, Jeffrey F. Piccirillo, Warren E. Rose
  • Impact of an Antimicrobial Stewardship Intervention on Within- and Between-Patient Daptomycin Resistance Evolution in Vancomycin-Resistant <span class="named-content genus-species" id="named-content-1">Enterococcus faecium</span>
    Clinical Therapeutics
    Impact of an Antimicrobial Stewardship Intervention on Within- and Between-Patient Daptomycin Resistance Evolution in Vancomycin-Resistant Enterococcus faecium

    Vancomycin-resistant Enterococcus (VRE) is a leading cause of hospital-acquired infection, with limited treatment options. Resistance to one of the few remaining drugs, daptomycin, is a growing clinical problem and has previously been described in this hospital.

    Clare L. Kinnear, Twisha S. Patel, Carol L. Young, Vincent Marshall, Duane W. Newton, Andrew F. Read, Robert J. Woods
  • Carbapenem versus Cefepime or Piperacillin-Tazobactam for Empiric Treatment of Bacteremia Due to Extended-Spectrum-β-Lactamase-Producing <em>Escherichia coli</em> in Patients with Hematologic Malignancy
    Clinical Therapeutics
    Carbapenem versus Cefepime or Piperacillin-Tazobactam for Empiric Treatment of Bacteremia Due to Extended-Spectrum-β-Lactamase-Producing Escherichia coli in Patients with Hematologic Malignancy

    Infections with extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli are common in patients with hematologic malignancy. The utility of cefepime and piperacillin-tazobactam as empiric therapy for ESBL-producing E. coli bacteremia in patients with hematologic malignancy is largely unknown...

    Grace E. Benanti, Anne Rain T. Brown, Terri Lynn Shigle, Jeffrey J. Tarrand, Micah M. Bhatti, Patrick M. McDaneld, Samuel A. Shelburne, Samuel L. Aitken
  • A Systematic Review of Single-Dose Aminoglycoside Therapy for Urinary Tract Infection: Is It Time To Resurrect an Old Strategy?
    Clinical Therapeutics
    A Systematic Review of Single-Dose Aminoglycoside Therapy for Urinary Tract Infection: Is It Time To Resurrect an Old Strategy?

    Increasing bacterial resistance and poor patient adherence rates limit the effectiveness of conventional antibiotic therapies for urinary tract infection (UTI). The objective of this study was to investigate whether a single aminoglycoside dose adequately treated UTI.

    Kellie J. Goodlet, Fatima Z. Benhalima, Michael D. Nailor
  • Implementation of Rapid Diagnostic Testing without Active Stewardship Team Notification for Gram-Positive Blood Cultures in a Community Teaching Hospital
    Clinical Therapeutics
    Implementation of Rapid Diagnostic Testing without Active Stewardship Team Notification for Gram-Positive Blood Cultures in a Community Teaching Hospital

    In community hospitals, antimicrobial stewardship team notification of rapid diagnostic testing (RDT) results may not be feasible. A retrospective quasi-experimental study was conducted evaluating 252 adult inpatients with blood cultures positive for Gram-positive cocci in clusters (pre-RDT, n = 143; post-RDT, n = 109).

    Paige M. Bukowski, Joshua S. Jacoby, Andrew P. Jameson, Lisa E. Dumkow
  • Epidemiology and Surveillance
    Prevalence of Inappropriate Antibiotic Prescribing in Primary Care Clinics within a Veterans Affairs Health Care System

    Data are needed from outpatient settings to better inform antimicrobial stewardship. In this study, a random sample of outpatient antibiotic prescriptions by primary care providers (PCPs) at our health care system was reviewed and compared to consensus guidelines.

    Nathan R. Shively, Deanna J. Buehrle, Cornelius J. Clancy, Brooke K. Decker
  • Epidemiology and Surveillance
    A Before-and-After Study of the Effectiveness of an Antimicrobial Stewardship Program in Critical Care
    Francisco Álvarez-Lerma, Santiago Grau, Daniel Echeverría-Esnal, Montserrat Martínez-Alonso, María Pilar Gracia-Arnillas, Juan Pablo Horcajada, Juan Ramón Masclans
  • Letter to the Editor
    Should Piperacillin-Tazobactam Be Used as Definitive Therapy against Enterobacteriaceae Harboring Inducible AmpC β-Lactamases?
    Samuel L. Aitken, Farnaz Foolad, Patrick M. McDaneld
  • Clinical Therapeutics
    Impact of a Carbapenem Antimicrobial Stewardship Program on Patient Outcomes
    Valerie Xue Fen Seah, Rina Yue Ling Ong, Ashley Shi Yuan Lim, Chia Yin Chong, Natalie Woon Hui Tan, Koh Cheng Thoon

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