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antitubercular agents

  • Increased Doses Lead to Higher Drug Exposures of Levofloxacin for Treatment of Tuberculosis
    Pharmacology
    Increased Doses Lead to Higher Drug Exposures of Levofloxacin for Treatment of Tuberculosis

    Patients with multidrug-resistant tuberculosis in Peru and South Africa were randomized to a weight-banded nominal dose of 11, 14, 17, or 20 mg/kg/day levofloxacin (minimum, 750 mg) in combination with other second-line agents. A total of 101 patients were included in noncompartmental pharmacokinetic analyses.

    Charles A. Peloquin, Patrick P. J. Phillips, Carole D. Mitnick, Kathleen Eisenach, Ramonde F. Patientia, Leonid Lecca, Eduardo Gotuzzo, Neel R. Gandhi, Donna Butler, Andreas H. Diacon, Bruno Martel, Juan Santillan, Kathleen Robergeau Hunt, Dante Vargas, Florian von Groote-Bidlingmaier, Carlos Seas, Nancy Dianis, Antonio Moreno-Martinez, Pawandeep Kaur, C. Robert Horsburgh
  • Mechanisms of Action: Physiological Effects
    The Alternative Sigma Factors SigE and SigB Are Involved in Tolerance and Persistence to Antitubercular Drugs
    Davide Pisu, Roberta Provvedi, Dulce Mata Espinosa, Jorge Barrios Payan, Francesca Boldrin, Giorgio Palù, Rogelio Hernandez-Pando, Riccardo Manganelli
  • Susceptibility
    Chemical Genetic Interaction Profiling Reveals Determinants of Intrinsic Antibiotic Resistance in Mycobacterium tuberculosis
    Weizhen Xu, Michael A. DeJesus, Nadine Rücker, Curtis A. Engelhart, Meredith G. Wright, Claire Healy, Kan Lin, Ruojun Wang, Sae Woong Park, Thomas R. Ioerger, Dirk Schnappinger, Sabine Ehrt
  • Mechanisms of Resistance
    Immunodeficiency and Intermittent Dosing Promote Acquired Rifamycin Monoresistance in Murine Tuberculosis
    Sang-Won Park, Rokeya Tasneen, Paul J. Converse, Eric L. Nuermberger
  • Chemistry; Biosynthesis
    N-Acetylglucosamine-1-Phosphate Transferase, WecA, as a Validated Drug Target in Mycobacterium tuberculosis
    Stanislav Huszár, Vinayak Singh, Alica Polčicová, Peter Baráth, María Belén Barrio, Sophie Lagrange, Véronique Leblanc, Carol A. Nacy, Valerie Mizrahi, Katarína Mikušová
  • Mechanisms of Resistance
    Bedaquiline Inhibits the ATP Synthase in Mycobacterium abscessus and Is Effective in Infected Zebrafish
    Christian Dupont, Albertus Viljoen, Sangeeta Thomas, Françoise Roquet-Banères, Jean-Louis Herrmann, Kevin Pethe, Laurent Kremer
  • Mechanisms of Resistance
    Mycobacterium tuberculosis Subculture Results in Loss of Potentially Clinically Relevant Heteroresistance
    John Z. Metcalfe, Elizabeth Streicher, Grant Theron, Rebecca E. Colman, Renee Penaloza, Christopher Allender, Darrin Lemmer, Robin M. Warren, David M. Engelthaler
  • Mechanisms of Action: Physiological Effects
    Dual Mechanism of Action of 5-Nitro-1,10-Phenanthroline against Mycobacterium tuberculosis
    Saqib Kidwai, Chan-Yong Park, Shradha Mawatwal, Prabhakar Tiwari, Myung Geun Jung, Tannu Priya Gosain, Pradeep Kumar, David Alland, Sandeep Kumar, Avinash Bajaj, Yun-Kyung Hwang, Chang Sik Song, Rohan Dhiman, Ill Young Lee, Ramandeep Singh
  • Susceptibility
    In Vitro Drug Susceptibility of Bedaquiline, Delamanid, Linezolid, Clofazimine, Moxifloxacin, and Gatifloxacin against Extensively Drug-Resistant Tuberculosis in Beijing, China
    Yu Pang, Zhaojing Zong, Fengmin Huo, Wei Jing, Yifeng Ma, Lingling Dong, Yunxu Li, Liping Zhao, Yuhong Fu, Hairong Huang
  • Clinical Therapeutics
    Population Pharmacokinetics of AZD-5847 in Adults with Pulmonary Tuberculosis
    Abdullah Alsultan, Jennifer J. Furin, Jeannine Du Bois, Elana van Brakel, Phalkun Chheng, Amour Venter, Bonnie Thiel, Sara A. Debanne, W. Henry Boom, Andreas H. Diacon, John L. Johnson, Charles A. Peloquin

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