antitubercular agents
PharmacologyIncreased Doses Lead to Higher Drug Exposures of Levofloxacin for Treatment of TuberculosisPatients with multidrug-resistant tuberculosis in Peru and South Africa were randomized to a weight-banded nominal dose of 11, 14, 17, or 20 mg/kg/day levofloxacin (minimum, 750 mg) in combination with other second-line agents. A total of 101 patients were included in noncompartmental pharmacokinetic analyses.
- Mechanisms of Action: Physiological EffectsThe Alternative Sigma Factors SigE and SigB Are Involved in Tolerance and Persistence to Antitubercular Drugs
- Mechanisms of Action: Physiological EffectsDual Mechanism of Action of 5-Nitro-1,10-Phenanthroline against Mycobacterium tuberculosis
- Clinical TherapeuticsPopulation Pharmacokinetics of AZD-5847 in Adults with Pulmonary Tuberculosis