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antiviral drugs

  • Investigational Antiviral Therapy Models for the Prevention and Treatment of Congenital Cytomegalovirus Infection during Pregnancy
    Antiviral Agents
    Investigational Antiviral Therapy Models for the Prevention and Treatment of Congenital Cytomegalovirus Infection during Pregnancy

    Congenital cytomegalovirus (HCMV) infection may cause significant fetal malformation, lifelong disease, and, in severe cases, fetal or neonatal death. Placental infection with HCMV is the major mechanism of mother-to-child transmission (MTCT) and fetal injury. Thus, any pharmaceutical antiviral interference to reduce viral load may reduce placental damage, MTCT, and fetal disease. However, there is currently no licensed HCMV antiviral...

    Stuart T. Hamilton, Manfred Marschall, William D. Rawlinson
  • Accelerating Drug Development through Repurposed FDA-Approved Drugs for COVID-19: Speed Is Important, Not Haste
    Letter to the Editor
    Accelerating Drug Development through Repurposed FDA-Approved Drugs for COVID-19: Speed Is Important, Not Haste
    James T. Gordy, Kaushiki Mazumdar, Noton K. Dutta
  • Free
    Updated Approaches against SARS-CoV-2
    Minireview
    Updated Approaches against SARS-CoV-2

    Novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lies behind the ongoing outbreak of coronavirus disease 2019 (COVID-19). There is a growing understanding of SARS-CoV-2 in virology, epidemiology, and clinical management strategies. However, no anti-SARS-CoV-2 drug or vaccine has been officially approved due to the absence of adequate evidence. Scientists are racing to develop a treatment for COVID-19. Recent studies...

    Haiou Li, Yunjiao Zhou, Meng Zhang, Haizhou Wang, Qiu Zhao, Jing Liu
  • Anti-HIV and Anti-Hepatitis C Virus Drugs Inhibit P-Glycoprotein Efflux Activity in Caco-2 Cells and Precision-Cut Rat and Human Intestinal Slices
    Antiviral Agents
    Anti-HIV and Anti-Hepatitis C Virus Drugs Inhibit P-Glycoprotein Efflux Activity in Caco-2 Cells and Precision-Cut Rat and Human Intestinal Slices

    P-glycoprotein (ABCB1), an ATP-binding-cassette efflux transporter, limits intestinal absorption of its substrates and is a common site of drug-drug interactions (DDIs). ABCB1 has been suggested to interact with many antivirals used to treat HIV and/or chronic hepatitis C virus (HCV) infections.

    Ondrej Martinec, Martin Huliciak, Frantisek Staud, Filip Cecka, Ivan Vokral, Lukas Cerveny
  • Antiviral Agents
    The Artemisinin Derivative Artemisone Is a Potent Inhibitor of Human Cytomegalovirus Replication
    E. Oiknine-Djian, Y. Weisblum, A. Panet, H. N. Wong, R. K. Haynes, D. G. Wolf
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