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antivirulence

  • Concurrent Local Delivery of Diflunisal Limits Bone Destruction but Fails To Improve Systemic Vancomycin Efficacy during <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Osteomyelitis
    Clinical Therapeutics
    Concurrent Local Delivery of Diflunisal Limits Bone Destruction but Fails To Improve Systemic Vancomycin Efficacy during Staphylococcus aureus Osteomyelitis

    Staphylococcus aureus osteomyelitis is a debilitating infection of bone. Treatment of osteomyelitis is impaired by the propensity of invading bacteria to induce pathological bone remodeling that may limit antibiotic penetration to the infectious focus. The nonsteroidal anti-inflammatory drug diflunisal was previously identified as an osteoprotective adjunctive therapy...

    Thomas J. Spoonmore, Caleb A. Ford, Jacob M. Curry, Scott A. Guelcher, James E. Cassat
  • Quinazoline-Based Antivirulence Compounds Selectively Target <em>Salmonella</em> PhoP/PhoQ Signal Transduction System
    Biologic Response Modifiers
    Quinazoline-Based Antivirulence Compounds Selectively Target Salmonella PhoP/PhoQ Signal Transduction System

    The rapid emergence of multidrug resistance among bacterial pathogens has become a significant challenge to human health in our century. Therefore, development of next-generation antibacterial compounds is an urgent need. Two-component signal transduction systems (TCS) are stimulus-response coupling devices that allow bacteria to sense and elaborate adaptive responses to changing environmental conditions, including the challenges that...

    María Ayelén Carabajal, Christopher R. M. Asquith, Tuomo Laitinen, Graham J. Tizzard, Lucía Yim, Analía Rial, José A. Chabalgoity, William J. Zuercher, Eleonora García Véscovi
  • Identification of FDA-Approved Drugs as Antivirulence Agents Targeting the <em>pqs</em> Quorum-Sensing System of <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span>
    Mechanisms of Action: Physiological Effects
    Identification of FDA-Approved Drugs as Antivirulence Agents Targeting the pqs Quorum-Sensing System of Pseudomonas aeruginosa

    The long-term use of antibiotics has led to the emergence of multidrug-resistant bacteria. A promising strategy to combat bacterial infections aims at hampering their adaptability to the host environment without affecting growth.

    Francesca D'Angelo, Valerio Baldelli, Nigel Halliday, Paolo Pantalone, Fabio Polticelli, Ersilia Fiscarelli, Paul Williams, Paolo Visca, Livia Leoni, Giordano Rampioni
  • Experimental Therapeutics
    Pharmacological Inhibition of the Pseudomonas aeruginosa MvfR Quorum-Sensing System Interferes with Biofilm Formation and Potentiates Antibiotic-Mediated Biofilm Disruption
    Damien Maura, Laurence G. Rahme
  • Clinical Therapeutics
    Exopolysaccharide-Repressing Small Molecules with Antibiofilm and Antivirulence Activity against Pseudomonas aeruginosa
    Erik van Tilburg Bernardes, Laetitia Charron-Mazenod, David J. Reading, Shauna L. Reckseidler-Zenteno, Shawn Lewenza
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