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augmented renal clearance

  • Urinary Creatinine Clearance and Pharmacokinetics Studies: If We Can Measure It, Why Do We Estimate It?
    Letter to the Editor
    Urinary Creatinine Clearance and Pharmacokinetics Studies: If We Can Measure It, Why Do We Estimate It?
    Catarina M. Silva, Andrew A. Udy, João P. Baptista
  • Population Pharmacokinetics of Amikacin Administered Once Daily in Patients with Different Renal Functions
    Clinical Therapeutics
    Population Pharmacokinetics of Amikacin Administered Once Daily in Patients with Different Renal Functions

    The aim of this work was to evaluate the pharmacokinetics of amikacin in Mexican patients with different renal functions receiving once-daily dosing regimens and the influence of clinical and demographical covariates that may influence the optimization of this antibiotic. A prospective study was performed in a total of 63 patients with at least one determination of amikacin plasma concentration. Population pharmacokinetic (PK)...

    Norma A. Aréchiga-Alvarado, Susanna E. Medellín-Garibay, Rosa del C. Milán-Segovia, Arturo Ortiz-Álvarez, Martín Magaña-Aquino, Silvia Romano-Moreno
  • Meropenem-Tobramycin Combination Regimens Combat Carbapenem-Resistant <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> in the Hollow-Fiber Infection Model Simulating Augmented Renal Clearance in Critically Ill Patients
    Pharmacology
    Meropenem-Tobramycin Combination Regimens Combat Carbapenem-Resistant Pseudomonas aeruginosa in the Hollow-Fiber Infection Model Simulating Augmented Renal Clearance in Critically Ill Patients

    Augmented renal clearance (ARC) is common in critically ill patients and is associated with subtherapeutic concentrations of renally eliminated antibiotics. We investigated the impact of ARC on bacterial killing and resistance amplification for meropenem and tobramycin regimens in monotherapy and combination. Two carbapenem-resistant Pseudomonas aeruginosa isolates...

    Rajbharan Yadav, Phillip J. Bergen, Kate E. Rogers, Carl M. J. Kirkpatrick, Steven C. Wallis, Yuling Huang, Jürgen B. Bulitta, David L. Paterson, Jeffrey Lipman, Roger L. Nation, Jason A. Roberts, Cornelia B. Landersdorfer
  • Are Standard Dosing Regimens of Ceftriaxone Adapted for Critically Ill Patients with Augmented Creatinine Clearance?
    Pharmacology
    Are Standard Dosing Regimens of Ceftriaxone Adapted for Critically Ill Patients with Augmented Creatinine Clearance?

    The objective of the present study was to determine whether augmented renal clearance (ARC) impacts negatively on ceftriaxone pharmacokinetic (PK)/pharmacodynamic (PD) target attainment in critically ill patients. Over a 9-month period, all critically ill patients treated with ceftriaxone were eligible.

    Julien Ollivier, Cédric Carrié, Nicolas d’Houdain, Sarah Djabarouti, Laurent Petit, Fabien Xuereb, Rachel Legeron, Matthieu Biais, Dominique Breilh
  • Pharmacology
    Population Pharmacokinetics of Piperacillin in Sepsis Patients: Should Alternative Dosing Strategies Be Considered?
    Maria Goul Andersen, Anders Thorsted, Merete Storgaard, Anders N. Kristoffersson, Lena E. Friberg, Kristina Öbrink-Hansen
  • Pharmacology
    Optimization and Evaluation of Piperacillin-Tobramycin Combination Dosage Regimens against Pseudomonas aeruginosa for Patients with Altered Pharmacokinetics via the Hollow-Fiber Infection Model and Mechanism-Based Modeling
    Rajbharan Yadav, Kate E. Rogers, Phillip J. Bergen, Jürgen B. Bulitta, Carl M. J. Kirkpatrick, Steven C. Wallis, David L. Paterson, Roger L. Nation, Jeffrey Lipman, Jason A. Roberts, Cornelia B. Landersdorfer
  • Pharmacology
    Substantial Impact of Altered Pharmacokinetics in Critically Ill Patients on the Antibacterial Effects of Meropenem Evaluated via the Dynamic Hollow-Fiber Infection Model
    Phillip J. Bergen, Jürgen B. Bulitta, Carl M. J. Kirkpatrick, Kate E. Rogers, Megan J. McGregor, Steven C. Wallis, David L. Paterson, Roger L. Nation, Jeffrey Lipman, Jason A. Roberts, Cornelia B. Landersdorfer
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