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autophagy

  • Open Access
    Autophagy Induction by a Small Molecule Inhibits <em>Salmonella</em> Survival in Macrophages and Mice
    Mechanisms of Action: Physiological Effects
    Autophagy Induction by a Small Molecule Inhibits Salmonella Survival in Macrophages and Mice

    Salmonella enterica is a natural bacterial pathogen of humans and animals that causes systemic infection or gastroenteritis. During systemic infection, Salmonella generally resides within professional phagocytes, typically macrophages, whereas gastroenteritis is caused by infection of epithelial cells. We are only beginning to understand which host pathways...

    Toni A. Nagy, Joaquin L. J. Quintana, Abigail L. Reens, Amy L. Crooks, Corrella S. Detweiler
  • Hepatotoxicity Induced by Isoniazid-Lipopolysaccharide through Endoplasmic Reticulum Stress, Autophagy, and Apoptosis Pathways in Zebrafish
    Pharmacology
    Hepatotoxicity Induced by Isoniazid-Lipopolysaccharide through Endoplasmic Reticulum Stress, Autophagy, and Apoptosis Pathways in Zebrafish

    Isoniazid (INH) is a first-line antituberculosis drug. The incidence of adverse reactions accompanied by inflammation in the liver during drug administration to tuberculosis patients is high and severely affects clinical treatment.

    Yun Zhang, Juan Cen, Zhili Jia, Chung-Der Hsiao, Qing Xia, Xue Wang, Xiqiang Chen, Rongchun Wang, Zhenzhou Jiang, Luyong Zhang, Kechun Liu
  • Zidovudine-Mediated Autophagy Inhibition Enhances Mitochondrial Toxicity in Muscle Cells
    Antiviral Agents
    Zidovudine-Mediated Autophagy Inhibition Enhances Mitochondrial Toxicity in Muscle Cells

    Nucleoside reverse transcriptase inhibitors (NRTI), such as zidovudine (AZT), are constituents of HIV-1 therapy and are used for the prevention of mother-to-child transmission. Prolonged thymidine analogue exposure has been associated with mitochondrial toxicities to heart, liver, and skeletal muscle.

    H. Lin, M. V. Stankov, J. Hegermann, R. Budida, D. Panayotova-Dimitrova, R. E. Schmidt, G. M. N. Behrens
  • Experimental Therapeutics
    Ambroxol Induces Autophagy and Potentiates Rifampin Antimycobacterial Activity

    Host-directed therapy in tuberculosis is a potential adjunct to antibiotic chemotherapy directed at Mycobacterium tuberculosis. Ambroxol, a lead compound, emerged from a screen for autophagy-inducing drugs.

    Seong Won Choi, Yuexi Gu, Ryan Scott Peters, Padmini Salgame, Jerrold J. Ellner, Graham S. Timmins, Vojo Deretic
  • Experimental Therapeutics
    Characterization of Plasmodium Atg3-Atg8 Interaction Inhibitors Identifies Novel Alternative Mechanisms of Action in Toxoplasma gondii
    Joseph M. Varberg, Kaice A. LaFavers, Gustavo Arrizabalaga, William J. Sullivan
  • Mechanisms of Action: Physiological Effects
    Dual Mechanism of Action of 5-Nitro-1,10-Phenanthroline against Mycobacterium tuberculosis
    Saqib Kidwai, Chan-Yong Park, Shradha Mawatwal, Prabhakar Tiwari, Myung Geun Jung, Tannu Priya Gosain, Pradeep Kumar, David Alland, Sandeep Kumar, Avinash Bajaj, Yun-Kyung Hwang, Chang Sik Song, Rohan Dhiman, Ill Young Lee, Ramandeep Singh
  • Mechanisms of Action: Physiological Effects
    Aziridine-2,3-Dicarboxylate-Based Cysteine Cathepsin Inhibitors Induce Cell Death in Leishmania major Associated with Accumulation of Debris in Autophagy-Related Lysosome-Like Vacuoles
    Uta Schurigt, Caroline Schad, Christin Glowa, Ulrike Baum, Katja Thomale, Johannes K. Schnitzer, Martina Schultheis, Norbert Schaschke, Tanja Schirmeister, Heidrun Moll
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