autophagy
Mechanisms of Action: Physiological EffectsAutophagy Induction by a Small Molecule Inhibits Salmonella Survival in Macrophages and MiceSalmonella enterica is a natural bacterial pathogen of humans and animals that causes systemic infection or gastroenteritis. During systemic infection, Salmonella generally resides within professional phagocytes, typically macrophages, whereas gastroenteritis is caused by infection of epithelial cells. We are only beginning to understand which host pathways...
PharmacologyHepatotoxicity Induced by Isoniazid-Lipopolysaccharide through Endoplasmic Reticulum Stress, Autophagy, and Apoptosis Pathways in ZebrafishIsoniazid (INH) is a first-line antituberculosis drug. The incidence of adverse reactions accompanied by inflammation in the liver during drug administration to tuberculosis patients is high and severely affects clinical treatment.
Antiviral AgentsZidovudine-Mediated Autophagy Inhibition Enhances Mitochondrial Toxicity in Muscle CellsNucleoside reverse transcriptase inhibitors (NRTI), such as zidovudine (AZT), are constituents of HIV-1 therapy and are used for the prevention of mother-to-child transmission. Prolonged thymidine analogue exposure has been associated with mitochondrial toxicities to heart, liver, and skeletal muscle.
- Experimental TherapeuticsAmbroxol Induces Autophagy and Potentiates Rifampin Antimycobacterial Activity
Host-directed therapy in tuberculosis is a potential adjunct to antibiotic chemotherapy directed at Mycobacterium tuberculosis. Ambroxol, a lead compound, emerged from a screen for autophagy-inducing drugs.
- Mechanisms of Action: Physiological EffectsDual Mechanism of Action of 5-Nitro-1,10-Phenanthroline against Mycobacterium tuberculosis