autophagy
PharmacologyHepatotoxicity Induced by Isoniazid-Lipopolysaccharide through Endoplasmic Reticulum Stress, Autophagy, and Apoptosis Pathways in ZebrafishIsoniazid (INH) is a first-line antituberculosis drug. The incidence of adverse reactions accompanied by inflammation in the liver during drug administration to tuberculosis patients is high and severely affects clinical treatment.
Antiviral AgentsZidovudine-Mediated Autophagy Inhibition Enhances Mitochondrial Toxicity in Muscle CellsNucleoside reverse transcriptase inhibitors (NRTI), such as zidovudine (AZT), are constituents of HIV-1 therapy and are used for the prevention of mother-to-child transmission. Prolonged thymidine analogue exposure has been associated with mitochondrial toxicities to heart, liver, and skeletal muscle.
- Experimental TherapeuticsAmbroxol Induces Autophagy and Potentiates Rifampin Antimycobacterial Activity
Host-directed therapy in tuberculosis is a potential adjunct to antibiotic chemotherapy directed at Mycobacterium tuberculosis. Ambroxol, a lead compound, emerged from a screen for autophagy-inducing drugs.
- Mechanisms of Action: Physiological EffectsDual Mechanism of Action of 5-Nitro-1,10-Phenanthroline against Mycobacterium tuberculosis