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azithromycin

  • Evaluation of the Combination of Azithromycin and Naphthoquine in Animal Malaria Models
    Experimental Therapeutics
    Evaluation of the Combination of Azithromycin and Naphthoquine in Animal Malaria Models

    Combination therapy using drugs with different mechanisms of action is the current state of the art in antimalarial treatment. However, except for artemisinin-based combination therapies, only a few other combinations are now available. Increasing concern regarding the emergence and spread of artemisinin resistance in Plasmodium falciparum has led to a need for the...

    Zhu-Chun Bei, Guo-Fu Li, Jing-Hua Zhao, Min Zhang, Xiao-Guang Ji, Jing-Yan Wang
  • Antimicrobial Resistance of <span class="named-content genus-species" id="named-content-1">Neisseria gonorrhoeae</span> Isolates from High-Risk Men in Johannesburg, South Africa
    Epidemiology and Surveillance
    Antimicrobial Resistance of Neisseria gonorrhoeae Isolates from High-Risk Men in Johannesburg, South Africa

    Neisseria gonorrhoeae antimicrobial drug resistance has emerged worldwide; however, the situation in sub-Saharan Africa is not well documented. We investigated the molecular epidemiology and occurrence of antimicrobial resistance in Neisseria gonorrhoeae infections in two core transmission groups of...

    Liteboho D. Maduna, Marleen M. Kock, Brian M. J. W. van der Veer, Oscar Radebe, James McIntyre, Lieke B. van Alphen, Remco P. H. Peters
  • Genomic Characterization of <span class="named-content genus-species" id="named-content-1">Neisseria gonorrhoeae</span> Strains from 2016 U.S. Sentinel Surveillance Displaying Reduced Susceptibility to Azithromycin
    Epidemiology and Surveillance
    Genomic Characterization of Neisseria gonorrhoeae Strains from 2016 U.S. Sentinel Surveillance Displaying Reduced Susceptibility to Azithromycin

    In 2016, the proportion of Neisseria gonorrhoeae isolates with reduced susceptibility to azithromycin rose to 3.6%. A phylogenetic analysis of 334 N. gonorrhoeae isolates collected in 2016 revealed a single, geographically diverse lineage of isolates with MICs of 2 to 16 μg/ml that carried a mosaic-...

    Matthew W. Schmerer, A. Jeanine Abrams, Sandra Seby, Jesse C. Thomas, John Cartee, Sean Lucking, Eshaw Vidyaprakash, Cau D. Pham, Samera Sharpe, Kevin Pettus, Sancta B. St. Cyr, Elizabeth A. Torrone, Ellen N. Kersh, Antimicrobial-Resistant Neisseria gonorrhoeae Working Group, Kim M. Gernert, Antimicrobial-Resistant Neisseria gonorrhoeae Working Group
  • Azithromycin Phenotypic versus Clinical Resistance
    Letter to the Editor
    Azithromycin Phenotypic versus Clinical Resistance
    Paul H. Edelstein
  • Azithromycin Protects against Zika Virus Infection by Upregulating Virus-Induced Type I and III Interferon Responses
    Antiviral Agents
    Azithromycin Protects against Zika Virus Infection by Upregulating Virus-Induced Type I and III Interferon Responses

    Azithromycin (AZM) is a widely used antibiotic, with additional antiviral and anti-inflammatory properties that remain poorly understood. Although Zika virus (ZIKV) poses a significant threat to global health, there are currently no vaccines or effective therapeutics against it. Here, we report that AZM effectively suppresses ZIKV infection in vitro by targeting a late stage in the viral life cycle.

    Chunfeng Li, Shulong Zu, Yong-Qiang Deng, Dapei Li, Kislay Parvatiyar, Natalie Quanquin, Jingzhe Shang, Nina Sun, Jiaqi Su, Zhenyang Liu, Min Wang, Saba R. Aliyari, Xiao-Feng Li, Aiping Wu, Feng Ma, Yi Shi, Karin Nielsen-Saines, Jae U. Jung, Frank Xiao-Feng Qin, Cheng-Feng Qin, Genhong Cheng
  • Antibiotic Resistance and Azithromycin Resistance Mechanism of <span class="named-content genus-species" id="named-content-1">Legionella pneumophila</span> Serogroup 1 in China
    Mechanisms of Resistance
    Antibiotic Resistance and Azithromycin Resistance Mechanism of Legionella pneumophila Serogroup 1 in China

    Legionnaires’ disease, caused by Legionella pneumophila, has been treated primarily with antibiotics. However, few reports have been published on antibiotic-resistant Legionella in China. Our aim was to determine the azithromycin resistance mechanism of L. pneumophila serogroup 1 in China...

    Xueyang Jia, Hongyu Ren, Xudong Nie, Yinan Li, Jianguo Li, Tian Qin
  • A Randomized Open-Label Evaluation of the Antimalarial Prophylactic Efficacy of Azithromycin-Piperaquine versus Sulfadoxine-Pyrimethamine in Pregnant Papua New Guinean Women
    Clinical Therapeutics
    A Randomized Open-Label Evaluation of the Antimalarial Prophylactic Efficacy of Azithromycin-Piperaquine versus Sulfadoxine-Pyrimethamine in Pregnant Papua New Guinean Women

    Emerging malaria parasite sulfadoxine-pyrimethamine (SP) resistance has prompted assessment of alternatives for intermittent preventive treatment in pregnancy (IPTp). The objective was to evaluate the tolerability and prophylactic efficacy of azithromycin (AZ) plus piperaquine (PQ) in pregnant women in Papua New Guinea. The study was an open-label, randomized, parallel-group trial.

    Brioni R. Moore, John M. Benjamin, Roselyn Tobe, Maria Ome-Kaius, Gumul Yadi, Bernadine Kasian, Charles Kong, Leanne J. Robinson, Moses Laman, Ivo Mueller, Stephen Rogerson, Timothy M. E. Davis
  • Efficacy of Azithromycin in a Mouse Pneumonia Model against Hospital-Acquired Methicillin-Resistant <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span>
    Experimental Therapeutics
    Efficacy of Azithromycin in a Mouse Pneumonia Model against Hospital-Acquired Methicillin-Resistant Staphylococcus aureus

    The use of macrolides against pneumonia has been reported to improve survival; however, little is known about their efficacy against methicillin-resistant Staphylococcus aureus (MRSA) pneumonia. In this study, we investigated the effect of azithromycin (AZM) and compared it with that of vancomycin (VCM) and daptomycin (DAP) in a murine model of MRSA pneumonia. Mice...

    Yu Yamashita, Kentaro Nagaoka, Hiroki Kimura, Masaru Suzuki, Satoshi Konno, Tatsuya Fukumoto, Koji Akizawa, Norihito Kaku, Yoshitomo Morinaga, Katsunori Yanagihara
  • Impact of Species Diversity on the Design of RNA-Based Diagnostics for Antibiotic Resistance in <em>Neisseria gonorrhoeae</em>
    Susceptibility
    Impact of Species Diversity on the Design of RNA-Based Diagnostics for Antibiotic Resistance in Neisseria gonorrhoeae

    Quantitative assessment of antibiotic-responsive RNA transcripts holds promise for a rapid point-of-care (POC) diagnostic tool for antimicrobial susceptibility testing. These assays aim to distinguish susceptible and resistant isolates by transcriptional differences upon drug exposure. However, an often-overlooked dimension of designing these tests is that the genetic diversity within a species may yield differential transcriptional...

    Crista B. Wadsworth, Mohamad R. A. Sater, Roby P. Bhattacharyya, Yonatan H. Grad
  • Role of Therapeutic Drug Monitoring in Treatment Optimization in Tuberculosis and Diabetes Mellitus Comorbidity
    Letter to the Editor
    Role of Therapeutic Drug Monitoring in Treatment Optimization in Tuberculosis and Diabetes Mellitus Comorbidity
    B. G. J. Dekkers, O. W. Akkerman, J. W. C. Alffenaar

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