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Bacillus subtilis

  • Open Access
    BceAB-Type Antibiotic Resistance Transporters Appear To Act by Target Protection of Cell Wall Synthesis
    Mechanisms of Resistance
    BceAB-Type Antibiotic Resistance Transporters Appear To Act by Target Protection of Cell Wall Synthesis

    Resistance against cell wall-active antimicrobial peptides in bacteria is often mediated by transporters. In low-GC-content Gram-positive bacteria, a common type of such transporters is BceAB-like systems, which frequently provide high-level resistance against peptide antibiotics that target intermediates of the lipid II cycle of cell wall synthesis. How a transporter can offer protection from drugs that are active on the cell surface,...

    Carolin M. Kobras, Hannah Piepenbreier, Jennifer Emenegger, Andre Sim, Georg Fritz, Susanne Gebhard
  • Daptomycin Pore Formation and Stoichiometry Depend on Membrane Potential of Target Membrane
    Mechanisms of Action: Physiological Effects
    Daptomycin Pore Formation and Stoichiometry Depend on Membrane Potential of Target Membrane

    Daptomycin is a calcium-dependent lipodepsipeptide antibiotic clinically used to treat serious infections caused by Gram-positive pathogens. Its precise mode of action is somewhat controversial; the biggest issue is daptomycin pore formation, which we directly investigated here.

    Gabriela Seydlová, Albert Sokol, Petra Lišková, Ivo Konopásek, Radovan Fišer
  • Susceptibility
    Evaluation of Antifungal Efficacy of Three New Cyclic Lipopeptides of the Class Bacillomycin from Bacillus subtilis RLID 12.1
    Ramya Ramachandran, Manjari Shrivastava, Namitha N. Narayanan, Ram Lal Thakur, Arunaloke Chakrabarti, Utpal Roy
  • Antiviral Agents
    Anti-influenza Activity of a Bacillus subtilis Probiotic Strain
    Darya Starosila, Svetlana Rybalko, Ludmila Varbanetz, Naila Ivanskaya, Iryna Sorokulova
  • Analytical Procedures
    Screen for Inducers of Autolysis in Bacillus subtilis
    Shaun P. Falk, James W. Noah, Bernard Weisblum
  • Mechanisms of Action: Physiological Effects
    The Large Mechanosensitive Channel MscL Determines Bacterial Susceptibility to the Bacteriocin Sublancin 168
    Thijs R. H. M. Kouwen, Erik N. Trip, Emma L. Denham, Mark J. J. B. Sibbald, Jean-Yves F. Dubois, Jan Maarten van Dijl
  • Mechanisms of Action: Physiological Effects
    Novel Expression Vector for Secretion of Cecropin AD in Bacillus subtilis with Enhanced Antimicrobial Activity
    Xiang Chen, Faming Zhu, Yunhe Cao, Shiyan Qiao
  • Mechanisms of Action: Physiological Effects
    Genetic Analysis of Factors Affecting Susceptibility of Bacillus subtilis to Daptomycin
    Anna-Barbara Hachmann, Esther R. Angert, John D. Helmann
  • Mechanisms of Action: Physiological Effects
    Daptomycin versus Friulimicin B: In-Depth Profiling of Bacillus subtilis Cell Envelope Stress Responses
    Tina Wecke, Daniela Zühlke, Ulrike Mäder, Sina Jordan, Birgit Voigt, Stefan Pelzer, Harald Labischinski, Georg Homuth, Michael Hecker, Thorsten Mascher
  • Mechanisms of Resistance
    Mutations in Three Distinct Loci Cause Resistance to Peptide Deformylase Inhibitors in Bacillus subtilis
    Yann Duroc, Carmela Giglione, Thierry Meinnel

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