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Bacterial Toxins

  • Open Access
    Experimental Therapeutics
    Multimechanistic Monoclonal Antibodies (MAbs) Targeting Staphylococcus aureus Alpha-Toxin and Clumping Factor A: Activity and Efficacy Comparisons of a MAb Combination and an Engineered Bispecific Antibody Approach
    C. Tkaczyk, S. Kasturirangan, A. Minola, O. Jones-Nelson, V. Gunter, Y. Y. Shi, K. Rosenthal, V. Aleti, E. Semenova, P. Warrener, D. Tabor, C. K. Stover, D. Corti, G. Rainey, B. R. Sellman
  • Mechanisms of Resistance
    Identification and Characterization of the Multidrug Resistance Gene cfr in a Panton-Valentine Leukocidin-Positive Sequence Type 8 Methicillin-Resistant Staphylococcus aureus IVa (USA300) Isolate
    Anna C. Shore, Orla M. Brennan, Ralf Ehricht, Stefan Monecke, Stefan Schwarz, Peter Slickers, David C. Coleman
  • Mechanisms of Action: Physiological Effects
    Subinhibitory Concentrations of Protein Synthesis-Inhibiting Antibiotics Promote Increased Expression of the agr Virulence Regulator and Production of Phenol-Soluble Modulin Cytolysins in Community-Associated Methicillin-Resistant Staphylococcus aureus
    Hwang-Soo Joo, June L. Chan, Gordon Y. C. Cheung, Michael Otto
  • Experimental Therapeutics
    A Chimeric Protein That Functions as both an Anthrax Dual-Target Antitoxin and a Trivalent Vaccine
    Gaobing Wu, Yuzhi Hong, Aizhen Guo, Chunfang Feng, Sha Cao, Cheng-Cai Zhang, Ruiping Shi, Yadi Tan, Ziduo Liu
  • Experimental Therapeutics
    Radiolabeled Antibodies to Bacillus anthracis Toxins Are Bactericidal and Partially Therapeutic in Experimental Murine Anthrax
    Johanna Rivera, Antonio S. Nakouzi, Alfred Morgenstern, Frank Bruchertseifer, Ekaterina Dadachova, Arturo Casadevall
  • Mechanisms of Resistance
    The Chromosomal Toxin Gene yafQ Is a Determinant of Multidrug Tolerance for Escherichia coli Growing in a Biofilm
    Joe J. Harrison, William D. Wade, Sarah Akierman, Caterina Vacchi-Suzzi, Carol A. Stremick, Raymond J. Turner, Howard Ceri
  • Mechanisms of Action: Physiological Effects
    Surfactants, Aromatic and Isoprenoid Compounds, and Fatty Acid Biosynthesis Inhibitors Suppress Staphylococcus aureus Production of Toxic Shock Syndrome Toxin 1
    Peter J. McNamara, Rae Ellen Syverson, Kathy Milligan-Myhre, Olga Frolova, Sarah Schroeder, Joshua Kidder, Thanh Hoang, Richard A. Proctor
  • Experimental Therapeutics
    Efficient Neutralization of Antibody-Resistant Forms of Anthrax Toxin by a Soluble Receptor Decoy Inhibitor
    Shilpi Sharma, Diane Thomas, John Marlett, Marianne Manchester, John A. T. Young
  • Experimental Therapeutics
    Tolevamer, an Anionic Polymer, Neutralizes Toxins Produced by the BI/027 Strains of Clostridium difficile
    Paul L. Hinkson, Carol Dinardo, Daniel DeCiero, Jeffrey D. Klinger, Robert H. Barker
  • Experimental Therapeutics
    In Vivo Efficacy of β-Cyclodextrin Derivatives against Anthrax Lethal Toxin
    Mahtab Moayeri, Tanisha M. Robinson, Stephen H. Leppla, Vladimir A. Karginov

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