Bacterial Toxins

Open Access

Experimental Therapeutics
Multimechanistic Monoclonal Antibodies (MAbs) Targeting Staphylococcus aureus Alpha-Toxin and Clumping Factor A: Activity and Efficacy Comparisons of a MAb Combination and an Engineered Bispecific Antibody Approach
C. Tkaczyk, S. Kasturirangan, A. Minola, O. Jones-Nelson, V. Gunter, Y. Y. Shi, K. Rosenthal, V. Aleti, E. Semenova, P. Warrener, D. Tabor, C. K. Stover, D. Corti, G. Rainey, B. R. Sellman
Mechanisms of Resistance
Identification and Characterization of the Multidrug Resistance Gene cfr in a Panton-Valentine Leukocidin-Positive Sequence Type 8 Methicillin-Resistant Staphylococcus aureus IVa (USA300) Isolate
Anna C. Shore, Orla M. Brennan, Ralf Ehricht, Stefan Monecke, Stefan Schwarz, Peter Slickers, David C. Coleman
Mechanisms of Action: Physiological Effects
Subinhibitory Concentrations of Protein Synthesis-Inhibiting Antibiotics Promote Increased Expression of the agr Virulence Regulator and Production of Phenol-Soluble Modulin Cytolysins in Community-Associated Methicillin-Resistant Staphylococcus aureus
Hwang-Soo Joo, June L. Chan, Gordon Y. C. Cheung, Michael Otto
Experimental Therapeutics
A Chimeric Protein That Functions as both an Anthrax Dual-Target Antitoxin and a Trivalent Vaccine
Gaobing Wu, Yuzhi Hong, Aizhen Guo, Chunfang Feng, Sha Cao, Cheng-Cai Zhang, Ruiping Shi, Yadi Tan, Ziduo Liu
Experimental Therapeutics
Radiolabeled Antibodies to Bacillus anthracis Toxins Are Bactericidal and Partially Therapeutic in Experimental Murine Anthrax
Johanna Rivera, Antonio S. Nakouzi, Alfred Morgenstern, Frank Bruchertseifer, Ekaterina Dadachova, Arturo Casadevall
Mechanisms of Resistance
The Chromosomal Toxin Gene yafQ Is a Determinant of Multidrug Tolerance for Escherichia coli Growing in a Biofilm
Joe J. Harrison, William D. Wade, Sarah Akierman, Caterina Vacchi-Suzzi, Carol A. Stremick, Raymond J. Turner, Howard Ceri
Mechanisms of Action: Physiological Effects
Surfactants, Aromatic and Isoprenoid Compounds, and Fatty Acid Biosynthesis Inhibitors Suppress Staphylococcus aureus Production of Toxic Shock Syndrome Toxin 1
Peter J. McNamara, Rae Ellen Syverson, Kathy Milligan-Myhre, Olga Frolova, Sarah Schroeder, Joshua Kidder, Thanh Hoang, Richard A. Proctor
Experimental Therapeutics
Efficient Neutralization of Antibody-Resistant Forms of Anthrax Toxin by a Soluble Receptor Decoy Inhibitor
Shilpi Sharma, Diane Thomas, John Marlett, Marianne Manchester, John A. T. Young
Experimental Therapeutics
Tolevamer, an Anionic Polymer, Neutralizes Toxins Produced by the BI/027 Strains of Clostridium difficile
Paul L. Hinkson, Carol Dinardo, Daniel DeCiero, Jeffrey D. Klinger, Robert H. Barker
Experimental Therapeutics
In Vivo Efficacy of β-Cyclodextrin Derivatives against Anthrax Lethal Toxin
Mahtab Moayeri, Tanisha M. Robinson, Stephen H. Leppla, Vladimir A. Karginov

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