bacterial translation

  • Open Access
    Experimental Therapeutics
    In Vitro and In Vivo Characterization of NOSO-502, a Novel Inhibitor of Bacterial Translation

    Antibacterial activity screening of a collection of Xenorhabdus strains led to the discovery of the odilorhabdins, a new antibiotic class with broad-spectrum activity against Gram-positive and Gram-negative pathogens. Odilorhabdins inhibit bacterial translation by a new mechanism of action on ribosomes.

    Emilie Racine, Patrice Nordmann, Lucile Pantel, Matthieu Sarciaux, Marine Serri, Jessica Houard, Philippe Villain-Guillot, Anthony Demords, Carina Vingsbo Lundberg, Maxime Gualtieri
  • Mechanisms of Action: Physiological Effects
    Potency of Solithromycin against Fast- and Slow-Growing Chlamydial Organisms

    Evidence is provided that solithromycin is a bactericidal against not only fast-growing chlamydial organisms but also those slowed by gamma interferon (IFN-γ) in vitro. At sublethal concentrations, Sol impedes homotypic fusion of Chlamydia-containing vacuoles and reduces secretion of the type III secretion (T3S) effector IncA.

    Leiqiong Gao, Yao Wang, Ziyu Hua, Enmei Liu, Li Shen
Back to top