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biomarker

  • <em>In Vitro</em> Evaluation of Radiolabeled Amphotericin B for Molecular Imaging of Mold Infections
    Chemistry; Biosynthesis
    In Vitro Evaluation of Radiolabeled Amphotericin B for Molecular Imaging of Mold Infections

    Invasive pulmonary aspergillosis and mucormycosis are life-threatening complications in immunocompromised patients. A rapid diagnosis followed by early antifungal treatment is essential for patient survival. Given the limited spectrum of biomarkers for invasive mold infections, recent studies have proposed the use of radiolabeled siderophores or antibodies as molecular probes to increase the specificity of radiological findings by...

    Lukas Page, Andrew J. Ullmann, Fabian Schadt, Sebastian Wurster, Samuel Samnick
  • Model-Based Relationship between the Molecular Bacterial Load Assay and Time to Positivity in Liquid Culture
    Editor's Pick Pharmacology
    Model-Based Relationship between the Molecular Bacterial Load Assay and Time to Positivity in Liquid Culture

    The molecular bacterial load (MBL) assay is a new tuberculosis biomarker which provides results in ∼4 hours. The relationship between MBL and time-to-positivity (TTP) has not been thoroughly studied, and predictive models do not exist. We aimed to develop a model for MBL and identify the MBL-TTP relationship in patients.

    Robin J. Svensson, Wilber Sabiiti, Gibson S. Kibiki, Nyanda E. Ntinginya, Nilesh Bhatt, Geraint Davies, Stephen H. Gillespie, Ulrika S. H. Simonsson
  • Comparative Performance of Urinary Biomarkers for Vancomycin-Induced Kidney Injury According to Timeline of Injury
    Pharmacology
    Comparative Performance of Urinary Biomarkers for Vancomycin-Induced Kidney Injury According to Timeline of Injury

    Urinary biomarkers are superior to serum creatinine for defining onset and extent of kidney injury. This study classifies the temporal predictive ability of biomarkers for vancomycin-induced kidney injury (VIKI) as defined by histopathologic damage.

    Gwendolyn M. Pais, Sean N. Avedissian, J. Nicholas O’Donnell, Nathaniel J. Rhodes, Thomas P. Lodise, Walter C. Prozialeck, Peter C. Lamar, Cameron Cluff, Anil Gulati, Julie C. Fitzgerald, Kevin J. Downes, Athena F. Zuppa, Marc H. Scheetz
  • Letter to the Editor
    Evaluation of Urinary KIM-1 for Prediction of Polymyxin B-Induced Nephrotoxicity
    Jessica T. Babic, Pooja Manchandani, Kimberly R. Ledesma, Vincent H. Tam
  • Antiviral Agents
    Upregulation of Apoptosis Pathway Genes in Peripheral Blood Mononuclear Cells of HIV-Infected Individuals with Antiretroviral Therapy-Associated Mitochondrial Toxicity
    Yram Foli, Musie Ghebremichael, Min Li, Elijah Paintsil
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