biomarker
Chemistry; BiosynthesisIn Vitro Evaluation of Radiolabeled Amphotericin B for Molecular Imaging of Mold InfectionsInvasive pulmonary aspergillosis and mucormycosis are life-threatening complications in immunocompromised patients. A rapid diagnosis followed by early antifungal treatment is essential for patient survival. Given the limited spectrum of biomarkers for invasive mold infections, recent studies have proposed the use of radiolabeled siderophores or antibodies as molecular probes to increase the specificity of radiological findings by...
Editor's Pick PharmacologyModel-Based Relationship between the Molecular Bacterial Load Assay and Time to Positivity in Liquid CultureThe molecular bacterial load (MBL) assay is a new tuberculosis biomarker which provides results in ∼4 hours. The relationship between MBL and time-to-positivity (TTP) has not been thoroughly studied, and predictive models do not exist. We aimed to develop a model for MBL and identify the MBL-TTP relationship in patients.
PharmacologyComparative Performance of Urinary Biomarkers for Vancomycin-Induced Kidney Injury According to Timeline of InjuryUrinary biomarkers are superior to serum creatinine for defining onset and extent of kidney injury. This study classifies the temporal predictive ability of biomarkers for vancomycin-induced kidney injury (VIKI) as defined by histopathologic damage.
- Letter to the EditorEvaluation of Urinary KIM-1 for Prediction of Polymyxin B-Induced Nephrotoxicity