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Borrelia burgdorferi

  • Patients with Erythema Migrans: Characterizing the Impact of Initiation of Antibiotic Therapy Prior to Study Enrollment
    Clinical Therapeutics
    Patients with Erythema Migrans: Characterizing the Impact of Initiation of Antibiotic Therapy Prior to Study Enrollment

    Erythema migrans is the most common clinical manifestation of Lyme disease, with concomitant subjective symptoms occurring in ∼65% of cases in the United States. We evaluated the impact of having been started on antibiotic treatment before study enrollment on 12 particular symptoms for 38 subjects with erythema migrans versus 52 untreated subjects. There were no significant differences in the frequency of having at least one symptom or...

    Gary P. Wormser, Donna McKenna, Eliana Jacobson, Elayna M. Shanker, Keith D. Shaffer, Carol Scavarda, Paul Visintainer
  • Molecular Testing of Serial Blood Specimens from Patients with Early Lyme Disease during Treatment Reveals Changing Coinfection with Mixtures of <span class="named-content genus-species" id="named-content-1">Borrelia burgdorferi</span> Genotypes
    Clinical Therapeutics
    Molecular Testing of Serial Blood Specimens from Patients with Early Lyme Disease during Treatment Reveals Changing Coinfection with Mixtures of Borrelia burgdorferi Genotypes

    Borrelia burgdorferi is the etiological agent of Lyme disease. In the current study, we used direct-detection PCR and electrospray ionization mass spectrometry to monitor and genotype B. burgdorferi isolates from serially collected whole-blood specimens from patients clinically diagnosed with early...

    Michael R. Mosel, Heather E. Carolan, Alison W. Rebman, Steven Castro, Christian Massire, David J. Ecker, Mark J. Soloski, John N. Aucott, Mark W. Eshoo
  • Identifying Vancomycin as an Effective Antibiotic for Killing <span class="named-content genus-species" id="named-content-1">Borrelia burgdorferi</span>
    Experimental Therapeutics
    Identifying Vancomycin as an Effective Antibiotic for Killing Borrelia burgdorferi

    Borrelia burgdorferi is the causative agent of Lyme borreliosis. Antibiotic therapy of early acute infection is effective for most patients, but 10 to 20% go on to develop posttreatment Lyme disease syndrome (PTLDS).

    Xiaoqian Wu, Bijaya Sharma, Samantha Niles, Kathleen O'Connor, Rebecca Schilling, Nicole Matluck, Anthony D'Onofrio, Linden T. Hu, Kim Lewis
  • Experimental Therapeutics
    Ineffectiveness of Tigecycline against Persistent Borrelia burgdorferi
    Stephen W. Barthold, Emir Hodzic, Denise M. Imai, Sunlian Feng, Xiaohua Yang, Benjamin J. Luft
  • Mechanisms of Resistance
    Borrelia burgdorferi Resistance to a Major Skin Antimicrobial Peptide Is Independent of Outer Surface Lipoprotein Content
    Amit Sarkar, Kit Tilly, Philip Stewart, Aaron Bestor, James M. Battisti, Patricia A. Rosa
  • Analytical Procedures
    High-Throughput Screening Identifies Three Inhibitor Classes of the Telomere Resolvase from the Lyme Disease Spirochete
    Georgia Lefas, George Chaconas
  • Susceptibility
    In Vitro Susceptibility of Borrelia spielmanii to Antimicrobial Agents Commonly Used for Treatment of Lyme Disease
    Kristina Morgenstern, Georg Baljer, Douglas E. Norris, Peter Kraiczy, Christa Hanssen-Hübner, Klaus-Peter Hunfeld
  • Experimental Therapeutics
    Persistence of Borrelia burgdorferi following Antibiotic Treatment in Mice
    Emir Hodzic, Sunlian Feng, Kevin Holden, Kimberly J. Freet, Stephen W. Barthold
  • Mechanisms of Resistance
    Mutations Conferring Aminoglycoside and Spectinomycin Resistance in Borrelia burgdorferi
    Daniel Criswell, Virginia L. Tobiason, J. Stephen Lodmell, D. Scott Samuels
  • Mechanisms of Resistance
    parC Mutations in Fluoroquinolone-Resistant Borrelia burgdorferi
    Kendal M. Galbraith, Amanda C. Ng, Betsy J. Eggers, Craig R. Kuchel, Christian H. Eggers, D. Scott Samuels

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