Skip to main content
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems
  • Log in
  • My alerts
  • My Cart

Main menu

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • COVID-19 Special Collection
    • Archive
    • Minireviews
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About AAC
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • AAC Podcast
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems

User menu

  • Log in
  • My alerts
  • My Cart

Search

  • Advanced search
Antimicrobial Agents and Chemotherapy
publisher-logosite-logo

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • COVID-19 Special Collection
    • Archive
    • Minireviews
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About AAC
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • AAC Podcast
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions

Burkholderia

  • <span class="named-content genus-species" id="named-content-1">Burkholderia ubonensis</span> High-Level Tetracycline Resistance Is Due to Efflux Pump Synergy Involving a Novel TetA(64) Resistance Determinant
    Mechanisms of Resistance
    Burkholderia ubonensis High-Level Tetracycline Resistance Is Due to Efflux Pump Synergy Involving a Novel TetA(64) Resistance Determinant

    Burkholderia ubonensis, a nonpathogenic soil bacterium belonging to the Burkholderia cepacia complex (Bcc), is highly resistant to some clinically significant antibiotics. The concern is that B. ubonensis may serve as a resistance reservoir for Bcc or...

    Nawarat Somprasong, Carina M. Hall, Jessica R. Webb, Jason W. Sahl, David M. Wagner, Paul Keim, Bart J. Currie, Herbert P. Schweizer
  • <em>In Vitro</em> Antibacterial Activity and <em>In Vivo</em> Efficacy of Sulbactam-Durlobactam against Pathogenic <em>Burkholderia</em> Species
    Experimental Therapeutics
    In Vitro Antibacterial Activity and In Vivo Efficacy of Sulbactam-Durlobactam against Pathogenic Burkholderia Species

    The Gram-negative bacterial genus Burkholderia includes several hard-to-treat human pathogens: two biothreat species, Burkholderia mallei (causing glanders) and B. pseudomallei (causing melioidosis), and the B. cepacia...

    Krisztina M. Papp-Wallace, Adam B. Shapiro, Scott A. Becka, Elise T. Zeiser, John J. LiPuma, Douglas J. Lane, Rekha G. Panchal, John P. Mueller, John P. O’Donnell, Alita A. Miller
  • Open Access
    GC-072, a Novel Therapeutic Candidate for Oral Treatment of Melioidosis and Infections Caused by Select Biothreat Pathogens
    Experimental Therapeutics
    GC-072, a Novel Therapeutic Candidate for Oral Treatment of Melioidosis and Infections Caused by Select Biothreat Pathogens

    Burkholderia pseudomallei, the etiological agent of melioidosis, is a Gram-negative bacterium with additional concern as a biothreat pathogen. The mortality rate from B. pseudomallei varies depending on the type of infection and extent of available health care; in the case of septicemia, left...

    Jeffry D. Shearer, Michelle L. Saylor, Christine M. Butler, Anthony M. Treston, Henry S. Heine, Sunisa Chirakul, Herbert P. Schweizer, Arnold Louie, George L. Drusano, Steven D. Zumbrun, Kelly L. Warfield
  • Efflux Pumps of <span class="named-content genus-species" id="named-content-1">Burkholderia thailandensis</span> Control the Permeability Barrier of the Outer Membrane
    Mechanisms of Resistance
    Efflux Pumps of Burkholderia thailandensis Control the Permeability Barrier of the Outer Membrane

    Burkholderia comprises species that are significant biothreat agents and common contaminants of pharmaceutical production facilities. Their extreme antibiotic resistance affects all classes of antibiotics, including polycationic polymyxins and aminoglycosides. The major underlying mechanism is the presence of two permeability barriers, the outer membrane with modified...

    Ganesh Krishnamoorthy, Jon W. Weeks, Zhen Zhang, Courtney E. Chandler, Haotian Xue, Herbert P. Schweizer, Robert K. Ernst, Helen I. Zgurskaya
  • Open Access
    <em>In Vitro</em> Activity of a Novel Glycopolymer against Biofilms of <span class="named-content genus-species" id="named-content-1">Burkholderia cepacia</span> Complex Cystic Fibrosis Clinical Isolates
    Mechanisms of Resistance
    In Vitro Activity of a Novel Glycopolymer against Biofilms of Burkholderia cepacia Complex Cystic Fibrosis Clinical Isolates

    Burkholderia cepacia complex (Bcc) lung infections in cystic fibrosis (CF) patients are often associated with a steady decline in lung function and death. The formation of biofilms and inherent multidrug resistance are virulence factors associated with Bcc infection and contribute to increased risk of mortality in CF patients.

    Vidya P. Narayanaswamy, Andrew P. Duncan, John J. LiPuma, William P. Wiesmann, Shenda M. Baker, Stacy M. Townsend
  • Various Evolutionary Trajectories Lead to Loss of the Tobramycin-Potentiating Activity of the Quorum-Sensing Inhibitor Baicalin Hydrate in <em>Burkholderia cenocepacia</em> Biofilms
    Mechanisms of Resistance
    Various Evolutionary Trajectories Lead to Loss of the Tobramycin-Potentiating Activity of the Quorum-Sensing Inhibitor Baicalin Hydrate in Burkholderia cenocepacia Biofilms

    Combining antibiotics with potentiators that increase their activity is a promising strategy to tackle infections caused by antibiotic-resistant bacteria. As potentiators do not interfere with essential processes, it has been hypothesized that they are less likely to induce resistance.

    Andrea Sass, Lisa Slachmuylders, Heleen Van Acker, Ian Vandenbussche, Lisa Ostyn, Mona Bové, Aurélie Crabbé, Laurent R. Chiarelli, Silvia Buroni, Filip Van Nieuwerburgh, Emmanuel Abatih, Tom Coenye
  • Resurrecting Old β-Lactams: Potent Inhibitory Activity of Temocillin against Multidrug-Resistant <em>Burkholderia</em> Species Isolates from the United States
    Mechanisms of Resistance
    Resurrecting Old β-Lactams: Potent Inhibitory Activity of Temocillin against Multidrug-Resistant Burkholderia Species Isolates from the United States

    Burkholderia spp. are opportunistic human pathogens that infect persons with cystic fibrosis and the immunocompromised.

    Elise T. Zeiser, Scott A. Becka, Melissa D. Barnes, Magdalena A. Taracila, John J. LiPuma, Krisztina M. Papp-Wallace
  • Open Access
    Competitive Fitness of Essential Gene Knockdowns Reveals a Broad-Spectrum Antibacterial Inhibitor of the Cell Division Protein FtsZ
    Mechanisms of Action: Physiological Effects
    Competitive Fitness of Essential Gene Knockdowns Reveals a Broad-Spectrum Antibacterial Inhibitor of the Cell Division Protein FtsZ

    To streamline the elucidation of antibacterial compounds’ mechanism of action, comprehensive high-throughput assays interrogating multiple putative targets are necessary. However, current chemogenomic approaches for antibiotic target identification have not fully utilized the multiplexing potential of next-generation sequencing.

    Andrew M. Hogan, Viola C. Scoffone, Vadim Makarov, April S. Gislason, Haben Tesfu, Maria S. Stietz, Ann Karen C. Brassinga, Michael Domaratzki, Xuan Li, Alberto Azzalin, Marco Biggiogera, Olga Riabova, Natalia Monakhova, Laurent R. Chiarelli, Giovanna Riccardi, Silvia Buroni, Silvia T. Cardona
  • Characterization of the AmpC β-Lactamase from <span class="named-content genus-species" id="named-content-1">Burkholderia multivorans</span>
    Mechanisms of Resistance
    Characterization of the AmpC β-Lactamase from Burkholderia multivorans

    Burkholderia multivorans is a member of the Burkholderia cepacia complex, a group of >20 related species of nosocomial pathogens that commonly infect individuals suffering from cystic fibrosis. β-Lactam antibiotics are recommended as therapy for infections due to B.

    Scott A. Becka, Elise T. Zeiser, Melissa D. Barnes, Magdalena A. Taracila, Kevin Nguyen, Indresh Singh, Granger G. Sutton, John J. LiPuma, Derrick E. Fouts, Krisztina M. Papp-Wallace
  • Susceptibility
    In Vitro Activity of Ceftolozane-Tazobactam and Other Antimicrobial Agents against Burkholderia cepacia Complex and Burkholderia gladioli
    Dale M. Mazer, Carol Young, Linda M. Kalikin, Theodore Spilker, John J. LiPuma

Pages

  • Next
  • 1
  • 2
Back to top

About

  • About AAC
  • Editor in Chief
  • Editorial Board
  • Policies
  • For Reviewers
  • For the Media
  • For Librarians
  • For Advertisers
  • Alerts
  • AAC Podcast
  • RSS
  • FAQ
  • Permissions
  • Journal Announcements

Authors

  • ASM Author Center
  • Submit a Manuscript
  • Article Types
  • Ethics
  • Contact Us

Follow #AACJournal

@ASMicrobiology

       

ASM Journals

ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology.

About ASM | Contact Us | Press Room

 

ASM is a member of

Scientific Society Publisher Alliance

 

American Society for Microbiology
1752 N St. NW
Washington, DC 20036
Phone: (202) 737-3600

Copyright © 2021 American Society for Microbiology | Privacy Policy | Website feedback

Print ISSN: 0066-4804; Online ISSN: 1098-6596