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cefotaxime

  • <em>In Vivo</em> Evolution of CTX-M-215, a Novel Narrow-Spectrum β-Lactamase in an <span class="named-content genus-species" id="named-content-1">Escherichia coli</span> Clinical Isolate Conferring Resistance to Mecillinam
    Mechanisms of Resistance
    In Vivo Evolution of CTX-M-215, a Novel Narrow-Spectrum β-Lactamase in an Escherichia coli Clinical Isolate Conferring Resistance to Mecillinam

    Here, we report a novel narrow-spectrum β-lactamase CTX-M-215 identified in an Escherichia coli clinical isolate in China and conferring high-level resistance to mecillinam but not to cefotaxime. CTX-M-215 differed from CTX-M-125, a CTX-M extended-spectrum β-lactamase (ESBL), by an N132D substitution, which decreased hydrolytic activities toward penicillins and...

    Mengyun Yin, Guoping Hu, Zhen Shen, Chengli Fang, Xuefei Zhang, Dan Li, Yohei Doi, Yu Zhang, Minggui Wang, Qinglan Guo
  • Meropenem versus Cefotaxime and Ampicillin as Empirical Antibiotic Treatment in Adult Bacterial Meningitis: a Quality Registry Study, 2008 to 2016
    Clinical Therapeutics
    Meropenem versus Cefotaxime and Ampicillin as Empirical Antibiotic Treatment in Adult Bacterial Meningitis: a Quality Registry Study, 2008 to 2016

    Cefotaxime, alone or with ampicillin, is frequently used in empirical treatment of acute bacterial meningitis (ABM). Meropenem is a less extensively investigated alternative. The aim of the study was to investigate the effects of empirical treatment with meropenem compared to cefotaxime plus ampicillin on outcome in ABM. The study was based on data from the Swedish quality register for ABM collected between January 2008 and December...

    Magnus Brink, Martin Glimåker, Jan Sjölin, Pontus Naucler
  • Structural Insights into Catalytic Relevances of Substrate Poses in ACC-1
    Mechanisms of Resistance
    Structural Insights into Catalytic Relevances of Substrate Poses in ACC-1

    ACC-1 is a plasmid-encoded class C β-lactamase identified in clinical isolates of Klebsiella pneumoniae, Proteus mirabilis, Salmonella enterica, and Escherichia coli...

    Da-Woon Bae, Ye-Eun Jung, Young Jun An, Jung-Hyun Na, Sun-Shin Cha
  • Ceftriaxone and Cefotaxime Have Similar Effects on the Intestinal Microbiota in Human Volunteers Treated by Standard-Dose Regimens
    Pharmacology
    Ceftriaxone and Cefotaxime Have Similar Effects on the Intestinal Microbiota in Human Volunteers Treated by Standard-Dose Regimens

    Ceftriaxone has a higher biliary elimination than cefotaxime (40% versus 10%), which may result in a more pronounced impact on the intestinal microbiota. We performed a monocenter, randomized open-label clinical trial in 22 healthy volunteers treated by intravenous ceftriaxone (1 g/24 h) or cefotaxime (1 g/8 h) for 3 days.

    Charles Burdet, Nathalie Grall, Morgane Linard, Antoine Bridier-Nahmias, Michèle Benhayoun, Khadija Bourabha, Mélanie Magnan, Olivier Clermont, Camille d’Humières, Olivier Tenaillon, Erick Denamur, Laurent Massias, Sarah Tubiana, Loubna Alavoine, Antoine Andremont, France Mentré, Xavier Duval, for the CEREMI Group
  • Whole-Genome Sequencing Analysis of Multidrug-Resistant Serotype 15A <span class="named-content genus-species" id="named-content-1">Streptococcus pneumoniae</span> in Japan and the Emergence of a Highly Resistant Serotype 15A-ST9084 Clone
    Mechanisms of Resistance
    Whole-Genome Sequencing Analysis of Multidrug-Resistant Serotype 15A Streptococcus pneumoniae in Japan and the Emergence of a Highly Resistant Serotype 15A-ST9084 Clone

    Since the introduction of pneumococcal conjugate vaccines (PCVs), an increase in the incidence of disease attributable to serotype 15A-ST63 (sequence type 63) pneumococci has been observed in many regions worldwide. We conducted a nationwide pediatric pneumococcal infection surveillance study between 2012 and 2014 in Japan.

    Satoshi Nakano, Takao Fujisawa, Yutaka Ito, Bin Chang, Yasufumi Matsumura, Masaki Yamamoto, Shigeru Suga, Makoto Ohnishi, Miki Nagao
  • Mechanisms of Resistance
    Defining Substrate Specificity in the CTX-M Family: the Role of Asp240 in Ceftazidime Hydrolysis
    Barbara Ghiglione, María Margarita Rodríguez, Lucrecia Curto, Florencia Brunetti, Milena Dropa, Robert A. Bonomo, Pablo Power, Gabriel Gutkind
  • Pharmacology
    Penetration of Cefotaxime into Cerebrospinal Fluid in Neonates and Young Infants
    Xing-Kai Chen, Hai-Yan Shi, Stephanie Leroux, Hai-Yan Xu, Yue Zhou, Yi Zheng, Xin Huang, Yan Li, Evelyne Jacqz-Aigrain, Wei Zhao
  • Clinical Therapeutics
    Population Pharmacokinetics of Cefotaxime and Dosage Recommendations in Children with Sickle Cell Disease
    Elsa Maksoud, Berengere Koehl, Aude Facchin, Phuong Ha, Wei Zhao, Florentia Kaguelidou, Malika Benkerrou, Patricia Mariani, Albert Faye, Mathie Lorrot, Evelyne Jacqz-Aigrain
  • Mechanisms of Resistance
    CTX-M-190, a Novel β-Lactamase Resistant to Tazobactam and Sulbactam, Identified in an Escherichia coli Clinical Isolate
    Zhen Shen, Baixing Ding, Yingmin Bi, Shi Wu, Su Xu, Xiaogang Xu, Qinglan Guo, Minggui Wang
  • Susceptibility
    In Vitro Synergism of Ciprofloxacin and Cefotaxime against Nalidixic Acid-Resistant Salmonella enterica Serotypes Paratyphi A and Paratyphi B
    Ganesh Prasad Neupane, Dong-Min Kim, Sung Hun Kim, Bok Kwon Lee

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