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ceftriaxone

  • Effects of Antibiotic Treatment with Piperacillin/Tazobactam versus Ceftriaxone on the Composition of the Murine Gut Microbiota
    Clinical Therapeutics
    Effects of Antibiotic Treatment with Piperacillin/Tazobactam versus Ceftriaxone on the Composition of the Murine Gut Microbiota

    Effective antimicrobial stewardship requires a better understanding of the impact of different antibiotics on the gut microflora. Studies with humans are confounded by large interindividual variability and difficulty in identifying control cohorts.

    Carola Venturini, Bethany Bowring, Alicia Fajardo-Lubian, Carol Devine, Jonathan Iredell
  • Emergence of Resistance in <em>Klebsiella aerogenes</em> to Piperacillin-Tazobactam and Ceftriaxone
    Susceptibility
    Emergence of Resistance in Klebsiella aerogenes to Piperacillin-Tazobactam and Ceftriaxone

    We examined the effects of piperacillin-tazobactam (TZP) concentration and bacterial inoculum on in vitro killing and the emergence of resistance in Klebsiella aerogenes. The MICs for 15 clinical respiratory isolates were determined by broth microdilution for TZP and by Etest for ceftriaxone (CRO) and cefepime (FEP). The presence of resistance in TZP-...

    Marco M. Custodio, Daniel Sanchez, Beverly Anderson, Keenan L. Ryan, Carla Walraven, Renee-Claude Mercier
  • Is Once-Daily High-Dose Ceftriaxone plus Ampicillin an Alternative for <span class="named-content genus-species" id="named-content-1">Enterococcus faecalis</span> Infective Endocarditis in Outpatient Parenteral Antibiotic Therapy Programs?
    Experimental Therapeutics
    Is Once-Daily High-Dose Ceftriaxone plus Ampicillin an Alternative for Enterococcus faecalis Infective Endocarditis in Outpatient Parenteral Antibiotic Therapy Programs?

    Ceftriaxone administered as once-daily high-dose short infusion combined with ampicillin has been proposed for the treatment of Enterococcus faecalis infective endocarditis in outpatient parenteral antibiotic therapy programs (OPAT). This combination requires synergistic activity, but the attainment of ceftriaxone synergic concentration (Cs) with the regimen proposed...

    Laura Herrera-Hidalgo, Arístides de Alarcón, Luis Eduardo López-Cortes, Rafael Luque-Márquez, Luis Fernando López-Cortes, Alicia Gutiérrez-Valencia, María Victoria Gil-Navarro
    and on behalf of Grupo para el Estudio de las Infecciones Cardiovasculares de la Sociedad Andaluza de Enfermedades Infecciosas
  • Prediction of Unbound Ceftriaxone Concentration in Children: Simple Bioanalysis Method and Basic Mathematical Equation
    Analytical Procedures
    Prediction of Unbound Ceftriaxone Concentration in Children: Simple Bioanalysis Method and Basic Mathematical Equation

    The pharmacological activity of ceftriaxone depends on the unbound concentration. However, direct measurement of unbound concentrations is obstructive, and high individual variability of the unbound fraction of ceftriaxone was shown in children. We aim to evaluate and validate a method to predict unbound ceftriaxone concentrations in pediatric patients. Ninety-five pairs of concentrations (total and unbound) from 92 patients were...

    Min Kan, Hai-Yan Shi, Bing Han, Yue-E Wu, Qian Li, Zi-Xuan Guo, Xue Li, Guo-Xiang Hao, Yi Zheng, Le-Qun Su, Xin Huang, Zhong-Guo Sui, Wei Zhao
  • Antimicrobial Resistance of <span class="named-content genus-species" id="named-content-1">Neisseria gonorrhoeae</span> Isolates from High-Risk Men in Johannesburg, South Africa
    Epidemiology and Surveillance
    Antimicrobial Resistance of Neisseria gonorrhoeae Isolates from High-Risk Men in Johannesburg, South Africa

    Neisseria gonorrhoeae antimicrobial drug resistance has emerged worldwide; however, the situation in sub-Saharan Africa is not well documented. We investigated the molecular epidemiology and occurrence of antimicrobial resistance in Neisseria gonorrhoeae infections in two core transmission groups of...

    Liteboho D. Maduna, Marleen M. Kock, Brian M. J. W. van der Veer, Oscar Radebe, James McIntyre, Lieke B. van Alphen, Remco P. H. Peters
  • Optimal Dosing of Ceftriaxone in Infants Based on a Developmental Population Pharmacokinetic-Pharmacodynamic Analysis
    Pharmacology
    Optimal Dosing of Ceftriaxone in Infants Based on a Developmental Population Pharmacokinetic-Pharmacodynamic Analysis

    Ceftriaxone is a third-generation cephalosporin used to treat infants with community-acquired pneumonia. Currently, there is a large variability in the amount of ceftriaxone used for this purpose in this particular age group, and an evidence-based optimal dose is still unavailable. Therefore, we investigated the population pharmacokinetics of ceftriaxone in infants and performed a developmental pharmacokinetic-pharmacodynamic analysis...

    Ya-Kun Wang, Yue-E Wu, Xue Li, Li-Yuan Tian, Muhammad Wasim Khan, Bo-Hao Tang, Hai-Yan Shi, Yi Zheng, Guo-Xiang Hao, John van den Anker, Dian-Ping You, Wei Zhao
  • Population Pharmacokinetic Study of Ceftriaxone in Elderly Patients, Using Cystatin C-Based Estimates of Renal Function To Account for Frailty
    Pharmacology
    Population Pharmacokinetic Study of Ceftriaxone in Elderly Patients, Using Cystatin C-Based Estimates of Renal Function To Account for Frailty

    Ceftriaxone is widely used for respiratory and urinary infections in elderly and frail patients, but there are few pharmacokinetic studies. A prospective population pharmacokinetic study of ceftriaxone in adults over 65 years old was undertaken. Dried blood spots collected at baseline (predose) and 0.5, 1, 4, 8, and 24 h after administration of 1 g of ceftriaxone were assayed using a validated liquid chromatography-mass spectroscopy...

    Shu Jin Tan, Matthew Cockcroft, Madhu Page-Sharp, Glenn Arendts, Timothy M. E. Davis, Brioni R. Moore, Kevin T. Batty, Sam Salman, Laurens Manning
  • Comparative Plasma Pharmacokinetics of Ceftriaxone and Ertapenem in Normoalbuminemia, Hypoalbuminemia, and Albumin Replacement in a Sheep Model
    Pharmacology
    Comparative Plasma Pharmacokinetics of Ceftriaxone and Ertapenem in Normoalbuminemia, Hypoalbuminemia, and Albumin Replacement in a Sheep Model

    Optimal concentrations of unbound antimicrobials are essential for a maximum microbiological effect. Although hypoalbuminemia and albumin fluid resuscitation are common in critical care, the effects of different albumin concentrations on the unbound concentrations of highly protein-bound antimicrobials are not known. The aim of this study was to compare the effects of different albumin states on total and unbound concentrations of...

    Jayesh A. Dhanani, Benjamin Ahern, Liad Lupinsky, Karen Jackson, Steven C. Wallis, Mohd H. Abdul-Aziz, Jeffrey Lipman, Jason A. Roberts
  • Ampicillin and Ceftriaxone Solution Stability at Different Temperatures in Outpatient Parenteral Antimicrobial Therapy
    Clinical Therapeutics
    Ampicillin and Ceftriaxone Solution Stability at Different Temperatures in Outpatient Parenteral Antimicrobial Therapy

    The inclusion of ampicillin-containing regimens in outpatient parenteral antimicrobial therapy programs (OPAT) depends upon solution stability under conditions similar to those experienced in these programs. Lack of this information could hinder the inclusion in OPAT of patients suffering from Enterococcus faecalis infective endocarditis treated with ampicillin plus...

    L. Herrera-Hidalgo, L. E. López-Cortes, R. Luque-Márquez, J. Gálvez-Acebal, A. de Alarcón, L. F. López-Cortes, A. Gutiérrez-Valencia, M. V. Gil-Navarro
  • Comparison of Clinical Outcomes among Intensive Care Unit Patients Receiving One or Two Grams of Ceftriaxone Daily
    Clinical Therapeutics
    Comparison of Clinical Outcomes among Intensive Care Unit Patients Receiving One or Two Grams of Ceftriaxone Daily

    Intensive care unit (ICU) patients may experience ceftriaxone underexposure, but clinical outcomes data are lacking. The objective of this study was to determine the impact of ceftriaxone dosing on clinical outcomes among ICU patients without central nervous system (CNS) infection. A retrospective study of ICU patients receiving intravenous, empirical ceftriaxone for non-CNS infections was conducted. Patients ≥18 years of age who...

    Andrew Ackerman, Nathaniel R. Zook, Jeremy F. Siegrist, Charles F. Brummitt, Margaret M. Cook, Thomas J. Dilworth

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