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cell wall

  • Open Access
    Upregulation of PBP1B and LpoB in <em>cysB</em> Mutants Confers Mecillinam (Amdinocillin) Resistance in <span class="named-content genus-species" id="named-content-1">Escherichia coli</span>
    Mechanisms of Resistance
    Upregulation of PBP1B and LpoB in cysB Mutants Confers Mecillinam (Amdinocillin) Resistance in Escherichia coli

    Mecillinam (amdinocillin) is a β-lactam antibiotic that inhibits the essential penicillin-binding protein 2 (PBP2). In clinical isolates of Escherichia coli from urinary tract infections, inactivation of the cysB gene (which encodes the main regulator of cysteine biosynthesis, CysB) is the major cause of resistance. How a nonfunctional CysB protein confers...

    Elisabeth Thulin, Dan I. Andersson
  • Role of the <em>msaABCR</em> Operon in Cell Wall Biosynthesis, Autolysis, Integrity, and Antibiotic Resistance in <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span>
    Mechanisms of Resistance
    Role of the msaABCR Operon in Cell Wall Biosynthesis, Autolysis, Integrity, and Antibiotic Resistance in Staphylococcus aureus

    Staphylococcus aureus is an important human pathogen in both community and health care settings. One of the challenges with S. aureus as a pathogen is its acquisition of antibiotic resistance. Previously, we showed that deletion of the msaABCR operon reduces cell wall thickness, resulting...

    Bibek G C, Gyan S. Sahukhal, Mohamed O. Elasri
  • Role of MurT C-Terminal Domain in the Amidation of <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Peptidoglycan
    Mechanisms of Resistance
    Role of MurT C-Terminal Domain in the Amidation of Staphylococcus aureus Peptidoglycan

    Glutamate amidation, a secondary modification of the peptidoglycan, was first identified in Staphylococcus aureus. It is catalyzed by the protein products of the murT and gatD genes, which are conserved and colocalized in the genomes of most sequenced Gram-positive bacterial species. The MurT-GatD complex is required for cell viability, full...

    Bárbara V. Gonçalves, Raquel Portela, Ricardo Lobo, Teresa A. Figueiredo, Inês R. Grilo, Ana Madalena Ludovice, Hermínia de Lencastre, Jorge S. Dias, Rita G. Sobral
  • Susceptibility
    Chemical Genetic Interaction Profiling Reveals Determinants of Intrinsic Antibiotic Resistance in Mycobacterium tuberculosis
    Weizhen Xu, Michael A. DeJesus, Nadine Rücker, Curtis A. Engelhart, Meredith G. Wright, Claire Healy, Kan Lin, Ruojun Wang, Sae Woong Park, Thomas R. Ioerger, Dirk Schnappinger, Sabine Ehrt
  • Chemistry; Biosynthesis
    N-Acetylglucosamine-1-Phosphate Transferase, WecA, as a Validated Drug Target in Mycobacterium tuberculosis
    Stanislav Huszár, Vinayak Singh, Alica Polčicová, Peter Baráth, María Belén Barrio, Sophie Lagrange, Véronique Leblanc, Carol A. Nacy, Valerie Mizrahi, Katarína Mikušová
  • Mechanisms of Action: Physiological Effects
    Antibiotic Effects on Methicillin-Resistant Staphylococcus aureus Cytoplasmic Peptidoglycan Intermediate Levels and Evidence for Potential Metabolite Level Regulatory Loops
    Harika Vemula, Navid J. Ayon, Alloch Burton, William G. Gutheil
  • Mechanisms of Resistance
    Requirement of the CroRS Two-Component System for Resistance to Cell Wall-Targeting Antimicrobials in Enterococcus faecium
    Stephanie L. Kellogg, Jaime L. Little, Jessica S. Hoff, Christopher J. Kristich
  • Mechanisms of Resistance
    Tolerance to Caspofungin in Candida albicans Is Associated with at Least Three Distinctive Mechanisms That Govern Expression of FKS Genes and Cell Wall Remodeling
    Feng Yang, Lulu Zhang, Hironao Wakabayashi, Jason Myers, Yuanying Jiang, Yongbing Cao, Cristina Jimenez-Ortigosa, David S. Perlin, Elena Rustchenko
  • Mechanisms of Resistance
    TelA Contributes to the Innate Resistance of Listeria monocytogenes to Nisin and Other Cell Wall-Acting Antibiotics
    Barry Collins, Susan Joyce, Colin Hill, Paul D. Cotter, R. Paul Ross
  • Mechanisms of Resistance
    Cell Wall Thickening Is Not a Universal Accompaniment of the Daptomycin Nonsusceptibility Phenotype in Staphylococcus aureus: Evidence for Multiple Resistance Mechanisms
    Soo-Jin Yang, Cynthia C. Nast, Nagendra N. Mishra, Michael R. Yeaman, Paul D. Fey, Arnold S. Bayer

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