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cell wall synthesis

  • Pathway-Directed Screen for Inhibitors of the Bacterial Cell Elongation Machinery
    Mechanisms of Action: Physiological Effects
    Pathway-Directed Screen for Inhibitors of the Bacterial Cell Elongation Machinery

    New antibiotics are needed to combat the growing problem of resistant bacterial infections. An attractive avenue toward the discovery of such next-generation therapies is to identify novel inhibitors of clinically validated targets, like cell wall biogenesis.

    Jackson A. Buss, Vadim Baidin, Michael A. Welsh, Josué Flores-Kim, Hongbaek Cho, B. McKay Wood, Tsuyoshi Uehara, Suzanne Walker, Daniel Kahne, Thomas G. Bernhardt
  • Genetic Determinants of Penicillin Tolerance in <span class="named-content genus-species" id="named-content-1">Vibrio cholerae</span>
    Mechanisms of Resistance
    Genetic Determinants of Penicillin Tolerance in Vibrio cholerae

    Many bacteria are resistant to killing (tolerant) by typically bactericidal antibiotics due to their ability to counteract drug-induced cell damage. Vibrio cholerae, the cholera agent, displays an unusually high tolerance to diverse inhibitors of cell wall synthesis.

    Anna I. Weaver, Shannon G. Murphy, Benjamin D. Umans, Srikar Tallavajhala, Ikenna Onyekwere, Stephen Wittels, Jung-Ho Shin, Michael VanNieuwenhze, Matthew K. Waldor, Tobias Dörr
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