cell wall synthesis
Mechanisms of Action: Physiological EffectsPathway-Directed Screen for Inhibitors of the Bacterial Cell Elongation MachineryNew antibiotics are needed to combat the growing problem of resistant bacterial infections. An attractive avenue toward the discovery of such next-generation therapies is to identify novel inhibitors of clinically validated targets, like cell wall biogenesis.
Mechanisms of ResistanceGenetic Determinants of Penicillin Tolerance in Vibrio choleraeMany bacteria are resistant to killing (tolerant) by typically bactericidal antibiotics due to their ability to counteract drug-induced cell damage. Vibrio cholerae, the cholera agent, displays an unusually high tolerance to diverse inhibitors of cell wall synthesis.