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cephalosporins

  • A Systematic Review of Studies Reporting Antibiotic Pharmacokinetic Data in the Cerebrospinal Fluid of Critically Ill Patients with Uninflamed Meninges
    Clinical Therapeutics
    A Systematic Review of Studies Reporting Antibiotic Pharmacokinetic Data in the Cerebrospinal Fluid of Critically Ill Patients with Uninflamed Meninges

    Ventriculostomy-associated infections in critically ill patients remain therapeutically challenging because of drug- and disease-related factors that contribute to suboptimal antibiotic concentrations in cerebrospinal fluid. Optimal antibiotic dosing for the treatment and prevention of such infections should be based on robust and contextually specific pharmacokinetic data. The objects of this study were to describe and critically...

    Nilesh Kumta, Jason A. Roberts, Jeffrey Lipman, Wai Tat Wong, Gavin M. Joynt, Menino Osbert Cotta
  • Multiple Low-Reactivity Class B Penicillin-Binding Proteins Are Required for Cephalosporin Resistance in Enterococci
    Editor's Pick Mechanisms of Resistance
    Multiple Low-Reactivity Class B Penicillin-Binding Proteins Are Required for Cephalosporin Resistance in Enterococci

    Enterococcus faecalis and Enterococcus faecium are commensals of the gastrointestinal tract of most terrestrial organisms, including humans, and are major causes of health care-associated infections. Such infections are difficult or impossible to treat, as the enterococcal strains responsible are...

    Dušanka Djorić, Jaime L. Little, Christopher J. Kristich
  • <em>In Vitro</em> Activity of the New β-Lactamase Inhibitors Relebactam and Vaborbactam in Combination with β-Lactams against <span class="named-content genus-species" id="named-content-1">Mycobacterium abscessus</span> Complex Clinical Isolates
    Susceptibility
    In Vitro Activity of the New β-Lactamase Inhibitors Relebactam and Vaborbactam in Combination with β-Lactams against Mycobacterium abscessus Complex Clinical Isolates

    Pulmonary disease due to infection with Mycobacterium abscessus complex (MABC) is notoriously difficult to treat, in large part due to the intrinsic resistance of MABC strains to most antibiotics, including β-lactams. MABC organisms express a broad-spectrum β-lactamase that is resistant to traditional β-lactam-based β-lactamase inhibitors but inhibited by a newer non-...

    Amit Kaushik, Nicole C. Ammerman, Jin Lee, Olumide Martins, Barry N. Kreiswirth, Gyanu Lamichhane, Nicole M. Parrish, Eric L. Nuermberger
  • High Rate of Ceftobiprole Resistance among Clinical Methicillin-Resistant <em>Staphylococcus aureus</em> Isolates from a Hospital in Central Italy
    Mechanisms of Resistance
    High Rate of Ceftobiprole Resistance among Clinical Methicillin-Resistant Staphylococcus aureus Isolates from a Hospital in Central Italy

    Ceftobiprole is a fifth-generation cephalosporin with activity against methicillin-resistant Staphylococcus aureus (MRSA). One-year surveillance at the Regional Hospital of Ancona (Italy) disclosed a 12% ceftobiprole resistance rate (12/102 isolates; MIC, ≥4 mg/liter).

    Gianluca Morroni, Andrea Brenciani, Lucia Brescini, Simona Fioriti, Serena Simoni, Antonella Pocognoli, Marina Mingoia, Eleonora Giovanetti, Francesco Barchiesi, Andrea Giacometti, Oscar Cirioni
  • Epidemiology and Surveillance
    In Vitro Activities of Ceftaroline and Comparators against Streptococcus pneumoniae Isolates from U.S. Hospitals: Results from Seven Years of the AWARE Surveillance Program (2010 to 2016)
    Michael A. Pfaller, Rodrigo E. Mendes, Leonard R. Duncan, Robert K. Flamm, Helio S. Sader
  • Clinical Therapeutics
    Pharmacokinetics and Tissue Penetration of Ceftolozane-Tazobactam in Diabetic Patients with Lower Limb Infections and Healthy Adult Volunteers
    Marguerite L. Monogue, Sean M. Stainton, Arlinda Baummer-Carr, Ashley K. Shepard, James F. Nugent, Joseph L. Kuti, David P. Nicolau
  • Susceptibility
    Activity of Ceftolozane-Tazobactam and Ceftazidime-Avibactam against Beta-Lactam-Resistant Pseudomonas aeruginosa Isolates
    Romney M. Humphries, Janet A. Hindler, Annie Wong-Beringer, Shelley A. Miller
  • Susceptibility
    Efficacy of Ceftriaxone, Cefepime, Doxycycline, Ciprofloxacin, and Combination Therapy for Vibrio vulnificus Foodborne Septicemia
    Sonya A. Trinh, Hannah E. Gavin, Karla J. F. Satchell
  • Experimental Therapeutics
    Pharmacokinetics-Pharmacodynamics of CB-618 in Combination with Cefepime, Ceftazidime, Ceftolozane, or Meropenem: the Pharmacological Basis for a Stand-Alone β-Lactamase Inhibitor
    Paul G. Ambrose, Brian D. VanScoy, Michael Trang, Jennifer McCauley-Miller, Haley Conde, Sujata M. Bhavnani, Dylan C. Alexander, Lawrence V. Friedrich
  • Susceptibility
    In Vitro Comparison of Ceftolozane-Tazobactam to Traditional Beta-Lactams and Ceftolozane-Tazobactam as an Alternative to Combination Antimicrobial Therapy for Pseudomonas aeruginosa
    Kellie J. Goodlet, David P. Nicolau, Michael D. Nailor

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