chelator

  • Forging New Antibiotic Combinations under Iron-Limiting Conditions
    Experimental Therapeutics
    Forging New Antibiotic Combinations under Iron-Limiting Conditions

    Pseudomonas aeruginosa is a multidrug-resistant nosocomial pathogen. We showed previously that thiostrepton (TS), a Gram-positive thiopeptide antibiotic, is imported via pyoverdine receptors and synergizes with iron chelator deferasirox (DSX) to inhibit the growth of P. aeruginosa and...

    Derek C. K. Chan, Irene Guo, Lori L. Burrows
  • Open Access
    Mechanisms of Action: Physiological Effects
    Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals

    The lack of information regarding the mechanisms of action (MoA) or specific molecular targets of phenotypically active compounds can prove a barrier to their development as chemotherapeutic agents. Here, we report the results of our orthogonal genetic, molecular, and biochemical studies to determine the MoA of a novel 7-substituted 8-hydroxy-1,6-naphthyridine (8-HNT) series that displays promising activity against...

    Richard J. Wall, Sonia Moniz, Michael G. Thomas, Suzanne Norval, Eun-Jung Ko, Maria Marco, Timothy J. Miles, Ian H. Gilbert, David Horn, Alan H. Fairlamb, Susan Wyllie
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