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chitosan

  • Open Access
    Chitosan Ameliorates <span class="named-content genus-species" id="named-content-1">Candida auris</span> Virulence in a <span class="named-content genus-species" id="named-content-2">Galleria mellonella</span> Infection Model
    Experimental Therapeutics
    Chitosan Ameliorates Candida auris Virulence in a Galleria mellonella Infection Model

    Candida auris has emerged as a multidrug-resistant nosocomial pathogen over the last decade. Outbreaks of the organism in health care facilities have resulted in life-threatening invasive candidiasis in over 40 countries worldwide. Resistance by C. auris to conventional antifungal drugs such as...

    Laís Salomão Arias, Mark C. Butcher, Bryn Short, Emily McKloud, Chris Delaney, Ryan Kean, Douglas Roberto Monteiro, Craig Williams, Gordon Ramage, Jason L. Brown
  • Open Access
    Activity of Chitosan and Its Derivatives against <span class="named-content genus-species" id="named-content-1">Leishmania major</span> and <span class="named-content genus-species" id="named-content-2">Leishmania mexicana</span> <em>In Vitro</em>
    Experimental Therapeutics
    Activity of Chitosan and Its Derivatives against Leishmania major and Leishmania mexicana In Vitro

    There is an urgent need for safe, efficacious, affordable, and field-adapted drugs for the treatment of cutaneous leishmaniasis, which newly affects around 1.5 million people worldwide annually. Chitosan, a biodegradable cationic polysaccharide, has previously been reported to have antimicrobial, antileishmanial, and immunostimulatory activities.

    Alaa Riezk, John G. Raynes, Vanessa Yardley, Sudaxshina Murdan, Simon L. Croft
  • Biocompatibility and Targeting Efficiency of Encapsulated Quinapyramine Sulfate-Loaded Chitosan-Mannitol Nanoparticles in a Rabbit Model of Surra
    Experimental Therapeutics
    Biocompatibility and Targeting Efficiency of Encapsulated Quinapyramine Sulfate-Loaded Chitosan-Mannitol Nanoparticles in a Rabbit Model of Surra

    Quinapyramine sulfate (QS) produces trypanocidal effects against the parasite Trypanosoma evansi but is often poorly tolerated and causes serious reactions in animals. The encapsulation of QS in chitosan-mannitol to provide sustained release would improve both the therapeutic effect of QS and the quality of life of animals treated with this formulation.

    ...
    Anju Manuja, Balvinder Kumar, Rajender Kumar, Meenu Chopra, Neeraj Dilbaghi, Sandeep Kumar, Suresh C. Yadav
  • Experimental Therapeutics
    Chitinase Induction Prior to Caspofungin Treatment of Experimental Invasive Aspergillosis in Neutropenic Rats Does Not Enhance Survival
    Jeannine M. Refos, Alieke G. Vonk, Marian T. ten Kate, Henri A. Verbrugh, Irma A. J. M. Bakker-Woudenberg, Wendy W. J. van de Sande
  • Experimental Therapeutics
    Chitosan Acetate Bandage as a Topical Antimicrobial Dressing for Infected Burns
    Tianhong Dai, George P. Tegos, Marina Burkatovskaya, Ana P. Castano, Michael R. Hamblin
  • Mechanisms of Resistance
    New Plasmid-Mediated Fluoroquinolone Efflux Pump, QepA, Found in an Escherichia coli Clinical Isolate
    Kunikazu Yamane, Jun-ichi Wachino, Satowa Suzuki, Kouji Kimura, Naohiro Shibata, Haru Kato, Keigo Shibayama, Toshifumi Konda, Yoshichika Arakawa
  • Mechanisms of Action: Physiological Effects
    Chitosan Malate Inhibits Growth and Exotoxin Production of Toxic Shock Syndrome-Inducing Staphylococcus aureus Strains and Group A Streptococci
    Patrick M. Schlievert
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