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chloroquine

  • Open Access
    Chloroquine Potentiates Primaquine Activity against Active and Latent Hepatic Plasmodia <em>Ex Vivo</em>: Potentials and Pitfalls
    Experimental Therapeutics
    Chloroquine Potentiates Primaquine Activity against Active and Latent Hepatic Plasmodia Ex Vivo: Potentials and Pitfalls

    For a long while, 8-aminoquinoline compounds have been the only therapeutic agents against latent hepatic malaria parasites. These have poor activity against the blood-stage plasmodia causing acute malaria and must be used in conjunction with partner blood schizontocidal agents. We examined the impacts of one such agent, chloroquine, upon the activity of primaquine, an 8-aminoquinoline, against hepatic stages of...

    Laurent Dembélé, Jean-François Franetich, Valérie Soulard, Nadia Amanzougaghene, Shahin Tajeri, Teun Bousema, Geert-Jan van Gemert, Roger Le Grand, Nathalie Dereuddre-Bosquet, J. Kevin Baird, Dominique Mazier, Georges Snounou
  • Open Access
    Safety, Pharmacokinetics, and Activity of High-Dose Ivermectin and Chloroquine against the Liver Stage of <span class="named-content genus-species" id="named-content-1">Plasmodium cynomolgi</span> Infection in Rhesus Macaques
    Pharmacology
    Safety, Pharmacokinetics, and Activity of High-Dose Ivermectin and Chloroquine against the Liver Stage of Plasmodium cynomolgi Infection in Rhesus Macaques

    Previously, ivermectin (1 to 10 mg/kg of body weight) was shown to inhibit the liver-stage development of Plasmodium berghei in orally dosed mice. Here, ivermectin showed inhibition of the in vitro development of Plasmodium cynomolgi schizonts (50% inhibitory concentration [IC50...

    Pattaraporn Vanachayangkul, Rawiwan Im-erbsin, Anchalee Tungtaeng, Chanikarn Kodchakorn, Alison Roth, John Adams, Chaiyaporn Chaisatit, Piyaporn Saingam, Richard J. Sciotti, Gregory A. Reichard, Christina K. Nolan, Brandon S. Pybus, Chad C. Black, Luis A. Lugo-Roman, Matthew D. Wegner, Philip L. Smith, Mariusz Wojnarski, Brian A. Vesely, Kevin C. Kobylinski
  • Influence of <em>CYP2C8</em>, <em>CYP3A4</em>, and <em>CYP3A5</em> Host Genotypes on Early Recurrence of <span class="named-content genus-species" id="named-content-1">Plasmodium vivax</span>
    Mechanisms of Resistance
    Influence of CYP2C8, CYP3A4, and CYP3A5 Host Genotypes on Early Recurrence of Plasmodium vivax

    Cytochrome P450 (CYP) enzymes are involved in the biotransformation of chloroquine (CQ), but the role of the different profiles of metabolism of this drug in relation to Plasmodium vivax recurrences has not been properly investigated. To investigate the influence of the CYP genotypes associated with CQ metabolism on the rates of...

    Anne C. G. Almeida, Maria C. B. Puça, Erick F. G. Figueiredo, Laila R. Barbosa, Yanka E. A. R. Salazar, Emanuelle L. Silva, Marcelo A. M. Brito, André M. Siqueira, José L. F. Vieira, Marcus V. G. Lacerda, Wuelton M. Monteiro, Gisely C. Melo
  • High-Dose Chloroquine for Uncomplicated <span class="named-content genus-species" id="named-content-1">Plasmodium falciparum</span> Malaria Is Well Tolerated and Causes Similar QT Interval Prolongation as Standard-Dose Chloroquine in Children
    Clinical Therapeutics
    High-Dose Chloroquine for Uncomplicated Plasmodium falciparum Malaria Is Well Tolerated and Causes Similar QT Interval Prolongation as Standard-Dose Chloroquine in Children

    Higher chloroquine doses can effectively treat up to 93 to 96% of malaria infections caused by Plasmodium falciparum carrying the resistance-conferring chloroquine resistance transporter (pfcrt) 76T allele. The tolerability of 50 (double the standard dose) and 70 mg/kg total chloroquine doses were assessed in this study. Fifteen 4- to 8-year-old children with...

    Johan Ursing, Lars Rombo, Staffan Eksborg, Lena Larson, Anita Bruvoll, Joel Tarning, Amabelia Rodrigues, Poul-Erik Kofoed
  • Open Access
    Emergence of <span class="named-content genus-species" id="named-content-1">Plasmodium vivax</span> Resistance to Chloroquine in French Guiana
    Clinical Therapeutics
    Emergence of Plasmodium vivax Resistance to Chloroquine in French Guiana

    In South America, Plasmodium vivax resistance to chloroquine was recently reported in Brazil and Bolivia. The objective of this study was to collect data on chloroquine resistance in French Guiana by associating a retrospective evaluation of therapeutic efficacy with an analysis of recurrent parasitemia from any patients. Patients with...

    Lise Musset, Christophe Heugas, Richard Naldjinan, Denis Blanchet, Pascal Houze, Philippe Abboud, Béatrice Volney, Gaëlle Walter, Yassamine Lazrek, Loïc Epelboin, Stephane Pelleau, Pascal Ringwald, Eric Legrand, Magalie Demar, Félix Djossou
  • Monitoring the Efficacy of Chloroquine-Primaquine Therapy for Uncomplicated <span class="named-content genus-species" id="named-content-1">Plasmodium vivax</span> Malaria in the Main Transmission Hot Spot of Brazil
    Epidemiology and Surveillance
    Monitoring the Efficacy of Chloroquine-Primaquine Therapy for Uncomplicated Plasmodium vivax Malaria in the Main Transmission Hot Spot of Brazil

    Emerging Plasmodium vivax resistance to chloroquine (CQ) may undermine malaria elimination efforts in South America. CQ-resistant P. vivax has been found in the major port city of Manaus but not in the main malaria hot spots across the Amazon Basin of Brazil, where CQ is routinely coadministered...

    Simone Ladeia-Andrade, Maria José Menezes, Taís Nóbrega de Sousa, Ana Carolina R. Silvino, Jaques F. de Carvalho, Laís C. Salla, Odaílton A. Nery, Gladson N. P. de Melo, Rodrigo M. Corder, Priscila T. Rodrigues, Marcelo U. Ferreira
  • Chloroquine Analogues as Leads against <span class="named-content genus-species" id="named-content-1">Pneumocystis</span> Lung Pathogens
    Susceptibility
    Chloroquine Analogues as Leads against Pneumocystis Lung Pathogens

    The impact of Pneumocystis pneumonia (PcP) on morbidity and mortality remains substantial for immunocompromised individuals, including those afflicted by HIV infection, organ transplantation, cancer, autoimmune diseases, or subject to chemotherapy or corticosteroid-based therapies. Previous work from our group has shown that repurposing antimalarial compounds for PcP...

    Ana Gomes, Ricardo Ferraz, Lauren Ficker, Margaret S. Collins, Cristina Prudêncio, Melanie T. Cushion, Cátia Teixeira, Paula Gomes
  • Open Access
    Pharmacology
    Characterizing Blood-Stage Antimalarial Drug MIC Values In Vivo Using Reinfection Patterns
    James Watson, Cindy S. Chu, Joel Tarning, Nicholas J. White
  • Susceptibility
    Enhanced Ex Vivo Plasmodium vivax Intraerythrocytic Enrichment and Maturation for Rapid and Sensitive Parasite Growth Assays
    Gabriel W. Rangel, Martha A. Clark, Usheer Kanjee, Caeul Lim, Kathryn Shaw-Saliba, Maria José Menezes, Anjali Mascarenhas, Laura Chery, Edwin Gomes, Pradipsinh K. Rathod, Marcelo U. Ferreira, Manoj T. Duraisingh
  • Open Access
    Susceptibility
    Plasmodium falciparum and Plasmodium vivax Demonstrate Contrasting Chloroquine Resistance Reversal Phenotypes
    Grennady Wirjanata, Irene Handayuni, Pak Prayoga, Leo Leonardo, Dwi Apriyanti, Leily Trianty, Ruland Wandosa, Basbak Gobay, Enny Kenangalem, Jeanne Rini Poespoprodjo, Rintis Noviyanti, Dennis E. Kyle, Qin Cheng, Ric N. Price, Jutta Marfurt

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