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clindamycin

  • Ribosome-Mediated Attenuation of <em>vga</em>(A) Expression Is Shaped by the Antibiotic Resistance Specificity of Vga(A) Protein Variants
    Mechanisms of Resistance
    Ribosome-Mediated Attenuation of vga(A) Expression Is Shaped by the Antibiotic Resistance Specificity of Vga(A) Protein Variants

    Vga(A) protein variants confer different levels of resistance to lincosamides, streptogramin A, and pleuromutilins (LSAP) by displacing antibiotics from the ribosome. Here, we show that expression of vga(A) variants from Staphylococcus haemolyticus is regulated by cis-regulatory RNA in response to the LSAP antibiotics by the...

    Vladimir Vimberg, Jorunn Pauline Cavanagh, Michaela Novotna, Jakub Lenart, Bich Nguyen Thi Ngoc, Jana Vesela, Maria Pain, Marketa Koberska, Gabriela Balikova Novotna
  • Antimicrobial Susceptibility and Clonality of Vaginally Derived Multidrug-Resistant <em>Mobiluncus</em> Isolates in China
    Mechanisms of Resistance
    Antimicrobial Susceptibility and Clonality of Vaginally Derived Multidrug-Resistant Mobiluncus Isolates in China

    Here, the antimicrobial susceptibility, resistance mechanisms, and clonality of Mobiluncus sp. isolates recovered from gynecological outpatients in China were investigated. Compared to M. mulieris, M. curtisii exhibited higher antimicrobial resistance to metronidazole, clindamycin, and...

    Xueying Zhang, Yongying Bai, Long Zhang, Mohamed S. Draz, Zhi Ruan, Yuning Zhu
  • Kinetic Driver of Antibacterial Drugs against <em>Plasmodium falciparum</em> and Implications for Clinical Dosing
    Pharmacology
    Kinetic Driver of Antibacterial Drugs against Plasmodium falciparum and Implications for Clinical Dosing

    Antibacterial drugs are an important component of malaria therapy. We studied the interactions of clindamycin, tetracycline, chloramphenicol, and ciprofloxacin against Plasmodium falciparum under static and dynamic conditions. In microtiter plate assays (static conditions), and as expected, parasites displayed the delayed death response characteristic for apicoplast-...

    Emily Caton, Elizabeth Nenortas, Rahul P. Bakshi, Theresa A. Shapiro
  • Clinical Therapeutics
    Treating Anthrax-Induced Meningitis in Rabbits
    Amir Ben-Shmuel, Itai Glinert, Assa Sittner, Elad Bar-David, Josef Schlomovitz, Tal Brosh, David Kobiler, Shay Weiss, Haim Levy
  • Pharmacology
    Pharmacokinetics of Clindamycin in Obese and Nonobese Children
    Michael J. Smith, Daniel Gonzalez, Jennifer L. Goldman, Ram Yogev, Janice E. Sullivan, Michael D. Reed, Ravinder Anand, Karen Martz, Katherine Berezny, Daniel K. Benjamin, P. Brian Smith, Michael Cohen-Wolkowiez, Kevin Watt
    and on behalf of the Best Pharmaceuticals for Children Act—Pediatric Trials Network Steering Committee
  • Letter to the Editor
    Reply to “Modulatory Effects of a Subinhibitory Concentration of Clindamycin in Community-Acquired Methicillin-Resistant Staphylococcus aureus Strains of Sequence Type 30”
    Katrin Schilcher, Vanina Dengler Haunreiter, Annelies S. Zinkernagel
  • Letter to the Editor
    Modulatory Effects of a Subinhibitory Concentration of Clindamycin in Community-Acquired Methicillin-Resistant Staphylococcus aureus Strains of Sequence Type 30
    Chris K. Y. Wong, Lin Zheng, Margaret Ip
  • Mechanisms of Resistance
    Macrolide and Clindamycin Resistance in Streptococcus milleri Group Isolates from the Airways of Cystic Fibrosis Patients
    Margot E. Grinwis, Christopher D. Sibley, Michael D. Parkins, Christina S. Eshaghurshan, Harvey R. Rabin, Michael G. Surette
  • Pharmacology
    Pharmacokinetics of Clindamycin in Pregnant Women in the Peripartum Period
    Anouk E. Muller, Johan W. Mouton, Paul M. Oostvogel, P. Joep Dörr, Rob A. Voskuyl, Joost DeJongh, Eric A. P. Steegers, Meindert Danhof
  • Susceptibility
    In Vitro Activity of Mirincamycin (U24729A) against Plasmodium falciparum Isolates from Gabon
    Jana Held, Richard Westerman, Peter G. Kremsner, Benjamin Mordmüller

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