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coagulase-negative staphylococci

  • <em>In Vitro</em> Study of the Synergistic Effect of an Enzyme Cocktail and Antibiotics against Biofilms in a Prosthetic Joint Infection Model
    Experimental Therapeutics
    In Vitro Study of the Synergistic Effect of an Enzyme Cocktail and Antibiotics against Biofilms in a Prosthetic Joint Infection Model

    Prosthetic joint infections (PJI) are frequent complications of arthroplasties. Their treatment is made complex by the rapid formation of bacterial biofilms, limiting the effectiveness of antibiotic therapy.

    Hervé Poilvache, Albert Ruiz-Sorribas, Olivier Cornu, Françoise Van Bambeke
  • A Novel, Widespread <em>qacA</em> Allele Results in Reduced Chlorhexidine Susceptibility in <em>Staphylococcus epidermidis</em>
    Editor's Pick Mechanisms of Resistance
    A Novel, Widespread qacA Allele Results in Reduced Chlorhexidine Susceptibility in Staphylococcus epidermidis

    Chlorhexidine gluconate (CHG) is a topical antiseptic widely used in health care settings. In Staphylococcus spp., the pump QacA effluxes CHG, while the closely related QacB cannot due to a single amino acid substitution.

    Amin Addetia, Alexander L. Greninger, Amanda Adler, Shuhua Yuan, Negar Makhsous, Xuan Qin, Danielle M. Zerr
  • Evolution of Daptomycin Resistance in Coagulase-Negative Staphylococci Involves Mutations of the Essential Two-Component Regulator WalKR
    Mechanisms of Resistance
    Evolution of Daptomycin Resistance in Coagulase-Negative Staphylococci Involves Mutations of the Essential Two-Component Regulator WalKR

    Coagulase-negative staphylococci (CoNS) represent one of the major causes of health care- and medical device-associated infections. Emerging antimicrobial resistance has complicated the treatment of systemic infections caused by CoNS.

    Jhih-Hang Jiang, Carina Dexter, David R. Cameron, Ian R. Monk, Sarah L. Baines, Iain J. Abbott, Denis W. Spelman, Xenia Kostoulias, Cara Nethercott, Benjamin P. Howden, Anton Y. Peleg
  • Open Access
    Pentoxifylline Alone or in Combination with Gentamicin or Vancomycin Inhibits Live Microbe-Induced Proinflammatory Cytokine Production in Human Cord Blood and Cord Blood Monocytes <em>In Vitro</em>
    Biologic Response Modifiers
    Pentoxifylline Alone or in Combination with Gentamicin or Vancomycin Inhibits Live Microbe-Induced Proinflammatory Cytokine Production in Human Cord Blood and Cord Blood Monocytes In Vitro

    Neonatal sepsis and its accompanying inflammatory response contribute to substantial morbidity and mortality. Pentoxifylline (PTX), a phosphodiesterase inhibitor which suppresses transcription and production of proinflammatory cytokines, is a candidate adjunctive therapy for newborn sepsis.

    Esther M. Speer, Elizabeth Diago-Navarro, Lukasz S. Ozog, David J. Dowling, Wei Hou, Mahnoor Raheel, Bettina C. Fries, Ofer Levy
  • Implementation of Rapid Diagnostic Testing without Active Stewardship Team Notification for Gram-Positive Blood Cultures in a Community Teaching Hospital
    Clinical Therapeutics
    Implementation of Rapid Diagnostic Testing without Active Stewardship Team Notification for Gram-Positive Blood Cultures in a Community Teaching Hospital

    In community hospitals, antimicrobial stewardship team notification of rapid diagnostic testing (RDT) results may not be feasible. A retrospective quasi-experimental study was conducted evaluating 252 adult inpatients with blood cultures positive for Gram-positive cocci in clusters (pre-RDT, n = 143; post-RDT, n = 109).

    Paige M. Bukowski, Joshua S. Jacoby, Andrew P. Jameson, Lisa E. Dumkow
  • Deletion of One 23S rRNA Gene (<em>rrl</em>) Copy Contributes to the Development of Linezolid Resistance in <span class="named-content genus-species" id="named-content-1">Staphylococcus warneri</span>
    Letter to the Editor
    Deletion of One 23S rRNA Gene (rrl) Copy Contributes to the Development of Linezolid Resistance in Staphylococcus warneri
    Caroline Rouard, Florence Doucet-Populaire, Christelle Guillet-Caruba, Millie Villet, Nadège Bourgeois-Nicolaos
  • Open Access
    Genomic Analysis of Multiresistant <span class="named-content genus-species" id="named-content-1">Staphylococcus capitis</span> Associated with Neonatal Sepsis
    Epidemiology and Surveillance
    Genomic Analysis of Multiresistant Staphylococcus capitis Associated with Neonatal Sepsis

    Coagulase-negative staphylococci (CoNS), such as Staphylococcus capitis, are major causes of bloodstream infections in neonatal intensive care units (NICUs). Recently, a distinct clone of S. capitis (designated S. capitis NRCS-A)...

    Glen P. Carter, James E. Ussher, Anders Gonçalves Da Silva, Sarah L. Baines, Helen Heffernan, Thomas V. Riley, Roland Broadbent, Antje van der Linden, Jean Lee, Ian R. Monk, Timothy P. Stinear, Benjamin P. Howden, Deborah A. Williamson
  • Experimental Therapeutics
    High-Dose Daptomycin Is Effective as an Antibiotic Lock Therapy in a Rabbit Model of Staphylococcus epidermidis Catheter-Related Infection
    Jana Basas, Marta Palau, Carlos Ratia, José L. del Pozo, María Teresa Martín-Gómez, Xavier Gomis, Eduard Torrents, Benito Almirante, Joan Gavaldà
  • Experimental Therapeutics
    Efficient Killing of Planktonic and Biofilm-Embedded Coagulase-Negative Staphylococci by Bactericidal Protein P128
    Nethravathi Poonacha, Sandhya Nair, Srividya Desai, Darshan Tuppad, Deepika Hiremath, Thulasi Mohan, Aradhana Vipra, Umender Sharma
  • Mechanisms of Resistance
    A Novel erm(44) Gene Variant from a Human Staphylococcus saprophyticus Isolate Confers Resistance to Macrolides and Lincosamides but Not Streptogramins
    Christian Strauss, Yanmin Hu, Anthony Coates, Vincent Perreten
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