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conjugation

  • Open Access
    Simulating the Influence of Conjugative-Plasmid Kinetic Values on the Multilevel Dynamics of Antimicrobial Resistance in a Membrane Computing Model
    Mechanisms of Resistance
    Simulating the Influence of Conjugative-Plasmid Kinetic Values on the Multilevel Dynamics of Antimicrobial Resistance in a Membrane Computing Model

    Bacterial plasmids harboring antibiotic resistance genes are critical in the spread of antibiotic resistance. It is known that plasmids differ in their kinetic values, i.e., conjugation rate, segregation rate by copy number incompatibility with related plasmids, and rate of stochastic loss during replication. They also differ in cost to the cell in terms of reducing fitness and in the frequency of compensatory mutations compensating...

    Marcelino Campos, Álvaro San Millán, José M. Sempere, Val F. Lanza, Teresa M. Coque, Carlos Llorens, Fernando Baquero
  • The <em>mcr-9</em> Gene of <em>Salmonella</em> and <span class="named-content genus-species" id="named-content-1">Escherichia coli</span> Is Not Associated with Colistin Resistance in the United States
    Epidemiology and Surveillance
    The mcr-9 Gene of Salmonella and Escherichia coli Is Not Associated with Colistin Resistance in the United States

    Reports of transmissible colistin resistance show the importance of comprehensive colistin resistance surveillance. Recently, a new allele of the mobile colistin resistance (mcr) gene family designated mcr-9, which shows variation in genetic context and colistin susceptibility, was reported. We tested over 100 Salmonella enterica and...

    Gregory H. Tyson, Cong Li, Chih-Hao Hsu, Sherry Ayers, Stacey Borenstein, Sampa Mukherjee, Thu-Thuy Tran, Patrick F. McDermott, Shaohua Zhao
  • Development of Neutropenic Murine Models of Iron Overload and Depletion To Study the Efficacy of Siderophore-Antibiotic Conjugates
    Pharmacology
    Development of Neutropenic Murine Models of Iron Overload and Depletion To Study the Efficacy of Siderophore-Antibiotic Conjugates

    Siderophore-antibiotic conjugates have increased in vitro activity in low-iron environments where bacteria express siderophores and associated transporters. The host immune hypoferremic response reduces iron availability to bacteria; however, patients with iron overload or deficiency may have altered ability to restrict iron, which may affect the efficacy of siderophore-antibiotic conjugates. In vivo models of...

    James M. Kidd, Kamilia Abdelraouf, David P. Nicolau
  • Evolution of a 72-Kilobase Cointegrant, Conjugative Multiresistance Plasmid in Community-Associated Methicillin-Resistant <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Isolates from the Early 1990s
    Mechanisms of Resistance
    Evolution of a 72-Kilobase Cointegrant, Conjugative Multiresistance Plasmid in Community-Associated Methicillin-Resistant Staphylococcus aureus Isolates from the Early 1990s

    Horizontal transfer of plasmids encoding antimicrobial resistance and virulence determinants has been instrumental in Staphylococcus aureus evolution, including the emergence of community-associated methicillin-resistant S. aureus (CA-MRSA). In the early 1990s, the first CA-MRSA strain isolated in...

    Karina Yui Eto, Neville Firth, Amy M. Davis, Stephen M. Kwong, Marcelina Krysiak, Yung Thin Lee, Frances G. O’Brien, Warren B. Grubb, Geoffrey W. Coombs, Charles S. Bond, Joshua P. Ramsay
  • Conjugative Delivery of CRISPR-Cas9 for the Selective Depletion of Antibiotic-Resistant Enterococci
    Editor's Pick Mechanisms of Resistance
    Conjugative Delivery of CRISPR-Cas9 for the Selective Depletion of Antibiotic-Resistant Enterococci

    The innovation of new therapies to combat multidrug-resistant (MDR) bacteria is being outpaced by the continued rise of MDR bacterial infections. Of particular concern are hospital-acquired infections (HAIs) that are recalcitrant to antibiotic therapies. The Gram-positive intestinal pathobiont Enterococcus faecalis is associated with HAIs, and some strains are MDR....

    Marinelle Rodrigues, Sara W. McBride, Karthik Hullahalli, Kelli L. Palmer, Breck A. Duerkop
  • <em>In Silico</em> Typing and Comparative Genomic Analysis of IncFII<sub>K</sub> Plasmids and Insights into the Evolution of Replicons, Plasmid Backbones, and Resistance Determinant Profiles
    Mechanisms of Resistance
    In Silico Typing and Comparative Genomic Analysis of IncFIIK Plasmids and Insights into the Evolution of Replicons, Plasmid Backbones, and Resistance Determinant Profiles

    IncFIIK plasmids are associated with the acquisition and dissemination of multiple-antimicrobial resistance in Klebsiella pneumoniae and often encountered in clinical isolates of this species. Since the phylogeny and evolution of IncFIIK plasmids remain unclear, here we performed large-scale in silico typing and comparative analysis of...

    Dexi Bi, Jiayi Zheng, Jun-Jie Li, Zi-Ke Sheng, Xingchen Zhu, Hong-Yu Ou, Qianyu Li, Qing Wei
  • Mechanisms of Resistance
    Antibiotics Promote Escherichia coli-Pseudomonas aeruginosa Conjugation through Inhibiting Quorum Sensing
    Yang Lu, Jianming Zeng, Linjing Wang, Kai Lan, Shunmei E, Lina Wang, Qian Xiao, Qiang Luo, Xianzhang Huang, Bin Huang, Cha Chen
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